Immunohistochemical analysis of connective tissue in patients with pelvic organ prolapse

被引：31

作者：

Yucel, Nese ^{[1
,2
]}

Usta, Akin ^{[1
,2
]}

Guzin, Kadir ^{[1
,2
]}

Kanter, Mehmet ^{[3
]}

Bilgic, Ergun ^{[1
,2
]}

Ozel, Nurver Ozbay ^{[4
]}

Ozgul, Mustafa ^{[3
]}

机构：

[1] Istanbul Medeniyet Univ, Goztepe Training & Res Hosp, Clin Gynecol, TR-34730 Istanbul, Turkey

[2] Istanbul Medeniyet Univ, Goztepe Training & Res Hosp, Clin Obstet, TR-34730 Istanbul, Turkey

[3] Istanbul Medeniyet Univ, Dept Histol & Embryol, Fac Med, TR-34730 Istanbul, Turkey

[4] Fatih Sultan Mehmet Training & Res Hosp, Dept Pathol, Istanbul, Turkey

来源：

JOURNAL OF MOLECULAR HISTOLOGY | 2013年 / 44卷 / 01期

关键词：

Immunohistochemistry; Pelvic organ prolapse; Connective tissue; Patients; COLLAGEN TYPE-I; URINARY-INCONTINENCE; POSTMENOPAUSAL WOMEN; UTEROSACRAL LIGAMENTS; CARDINAL LIGAMENTS; UTERINE PROLAPSE; SKIN; EPIDEMIOLOGY; METABOLISM; EXPRESSION;

D O I：

10.1007/s10735-012-9456-5

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The uterosacral ligaments are an important part of the pelvic support system. The objective of this study was to compare the expression of collagen type I and collagen type III in the uterosacral ligament biopsies from women with and without pelvic organ prolapse (POP). The uterosacral ligament biopsies were obtained from women with POP (n = 29) and non-POP subjects (n = 35). Immunohistochemistry for collagen type I and collagen type III was performed on formalin-fixed and paraffin-embedded sections. The two groups were matched for age, body mass index, parity and postmenopausal status. The expression of collagen type I (p < 0.001) and collagen type III (p < 0.0001) differed between women with POP and non-POP subjects. There was decreased expression of collagen type I and increased expression of collagen type III in uterosacral ligaments of women with POP compared with non-POP subjects. This difference indicates a possible relationship between POP and the immunohistochemical expression of collagen type I and collagen type III in uterosacral ligaments.

引用

页码：97 / 102

页数：6

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