Nitric oxide dosed in short bursts at high concentrations may protect against Covid 19

被引:33
作者
Hedenstierna, Goran [1 ]
Chen, Luni [2 ]
Hedenstierna, Magnus [3 ]
Lieberman, Robert [4 ]
Fine, David H. [5 ]
机构
[1] Uppsala Univ, Dept Med Sci, Uppsala, Sweden
[2] Karolinska Inst, Dept MTC, Solna, Sweden
[3] Danderyd Hosp, Dept Infect Dis, Danderyd, Sweden
[4] Contello Consulting LLC, Mendham, NJ USA
[5] Pieto LLC, Melbourne, FL USA
来源
NITRIC OXIDE-BIOLOGY AND CHEMISTRY | 2020年 / 103卷
关键词
Nitric oxide; Smoking; Viral suppression; Covid-19; ACUTE RESPIRATORY SYNDROME; MAINSTREAM; INHALATION; SMOKING; TOBACCO;
D O I
10.1016/j.niox.2020.06.005
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
It has long been suggested that NO may inhibit an early stage in viral replication. Furthermore, in vitro tests have shown that NO inhibits the replication cycle of severe acute respiratory syndrome coronavirus. Despite smoking being listed as a risk factor to contract Covid-19, only a low proportion of the smokers suffered from SARS-corona infection in China 2003, and from Covid-19 in China, Europe and the US. We hypothesize, that the intermittent bursts of high NO concentration in cigarette smoke may be a mechanism in protecting against the virus. Mainstream smoke from cigarettes contains NO at peak concentrations of between about 250 ppm and 1350 ppm in each puff as compared to medicinal use of no more than 80 to a maximum of 160 ppm. The diffusion of NO through the cell wall to reach the virus should be significantly more effective at the very high NO concentration in the smoke, according to classic laws of physics. The only oxide of nitrogen in the mainstream smoke is NO, and the NO2 concentration that is inhaled is very low or undetectable, and methemoglobin levels are lower in smokers than non-smokers, reasonably explained by the breaths of air in between the puffs that wash out the NO. Specialized iNO machines can now be developed to provide the drug intermittently in short bursts at high concentration dose, which would then provide both a preventative drug for those at high risk, as well as an effective treatment, without the health hazards associated with smoking.
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页码:1 / 3
页数:3
相关论文
共 25 条
  • [1] Quantitative puff-by-puff-resolved characterization of selected toxic compounds in cigarette mainstream smoke
    Adam, T
    Mitschke, S
    Streibel, T
    Baker, RR
    Zimmermann, R
    [J]. CHEMICAL RESEARCH IN TOXICOLOGY, 2006, 19 (04) : 511 - 520
  • [2] Nitric oxide inhibits the replication cycle of severe acute respiratory syndrome coronavirus
    Åkerström, S
    Mousavi-Jazi, M
    Klingström, J
    Leijon, M
    Lundkvist, Å
    Mirazimi, A
    [J]. JOURNAL OF VIROLOGY, 2005, 79 (03) : 1966 - 1969
  • [3] COVID-19 and Smoking
    Berlin, Ivan
    Thomas, Daniel
    Le Faou, Anne-Laurence
    Cornuz, Jacques
    [J]. NICOTINE & TOBACCO RESEARCH, 2020, 22 (09) : 1650 - 1652
  • [4] METHEMOGLOBIN LEVELS IN SMOKERS AND NONSMOKERS
    BORLAND, C
    HARMES, K
    CRACKNELL, N
    MACK, D
    HIGENBOTTAM, T
    [J]. ARCHIVES OF ENVIRONMENTAL HEALTH, 1985, 40 (06): : 330 - 333
  • [5] Inhalation of nitric oxide in the treatment of severe acute respiratory syndrome: A rescue trial in Beijing
    Chen, LN
    Liu, P
    Gao, H
    Sun, B
    Chao, DS
    Wang, F
    Zhu, YJ
    Hedenstierna, R
    Wang, CG
    [J]. CLINICAL INFECTIOUS DISEASES, 2004, 39 (10) : 1531 - 1535
  • [6] Gaibazzi N., 2020, SMOKING PREVALENCE L, DOI [10.1101/2020.05.05.20092015, DOI 10.1101/2020.05.05.20092015]
  • [7] Clinical Characteristics of Covid-19 in New York City
    Goyal, Parag
    Choi, Justin J.
    Safford, Monika M.
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2020, 382 (24) : 2372 - 2374
  • [8] Inhaled NO and COVID-19
    Ignarro, Louis J.
    [J]. BRITISH JOURNAL OF PHARMACOLOGY, 2020, 177 (16) : 3848 - 3849
  • [9] Inhibition of SARS-coronavirus infection in vitro by S-nitroso-N-acetylpenicillamine, a nitric oxide donor compound
    Keyaerts, E
    Vijgen, L
    Chen, LN
    Maes, P
    Hedenstierna, G
    Van Ranst, M
    [J]. INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, 2004, 8 (04) : 223 - 226
  • [10] ACE-2 expression in the small airway epithelia of smokers and COPD patients: implications for COVID-19
    Leung, Janice M.
    Yang, Chen X.
    Tam, Anthony
    Shaipanich, Tawimas
    Hackett, Tillie-Louise
    Singhera, Gurpreet K.
    Dorscheid, Delbert R.
    Sin, Don D.
    [J]. EUROPEAN RESPIRATORY JOURNAL, 2020, 55 (05)