Multifunctional roles of gelsolin in health and diseases

被引：197

作者：

Li, Guo Hua ^{[1
]}

Arora, Pamela D. ^{[2
]}

Chen, Yu ^{[3
]}

McCulloch, Christopher A. ^{[2
]}

Liu, Peter ^{[1
,4
]}

机构：

[1] Toronto Gen Hosp, Univ Hlth Network, Toronto, ON M5G 2C4, Canada

[2] Univ Toronto, Fac Dent, Canadian Inst, Hlth Res Matrix Dynam Grp, Toronto, ON M5S 1A1, Canada

[3] Dr Everett Chalmers Reg Hosp, Horizon Hlth Network, Dept Lab Med, Fredericton, NB, Canada

[4] Univ Toronto, Canadian Inst Hlth Res Grp, Toronto, ON, Canada

来源：

MEDICINAL RESEARCH REVIEWS | 2012年 / 32卷 / 05期

关键词：

gelsolin; actin; apoptosis; cancer; cardiac remodeling; ACTIN-BINDING PROTEINS; AMYLOID BETA-PROTEIN; BREAST-CANCER CELLS; GEL-SOL TRANSFORMATION; HUMAN-PLASMA GELSOLIN; CYTOCHROME-C-OXIDASE; SMOOTH-MUSCLE-CELLS; ALZHEIMERS-DISEASE; FLIGHTLESS-I; DOWN-REGULATION;

D O I：

10.1002/med.20231

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Gelsolin, a Ca2+-regulated actin filament severing, capping, and nucleating protein, is an ubiquitous, multifunctional regulator of cell structure and metabolism. More recent data show that gelsolin can act as a transcriptional cofactor in signal transduction and its own expression and function can be influenced by epigenetic changes. Here, we review the functions of the plasma and cytoplasmic forms of gelsolin, and their manifold impacts on cancer, apoptosis, infection and inflammation, cardiac injury, pulmonary diseases, and aging. An improved understanding of the functions and regulatory mechanisms of gelsolin may lead to new considerations of this protein as a potential biomarker and/or therapeutic target.

引用

页码：999 / 1025

页数：27

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