Cancer nanomedicine: progress, challenges and opportunities

被引：4562
作者：
Shi, Jinjun [1 ,2 ]
Kantoff, Philip W. [3 ]
Wooster, Richard [4 ]
Farokhzad, Omid C. [1 ,2 ,5 ]
机构：
[1] Harvard Med Sch, Brigham & Womens Hosp, Ctr Nanomed, Boston, MA 02115 USA
[2] Harvard Med Sch, Brigham & Womens Hosp, Dept Anesthesiol, Boston, MA 02115 USA
[3] Mem Sloan Kettering Canc Ctr, Dept Med, New York, NY 10065 USA
[4] Tarveda Therapeut, Watertown, MA 02472 USA
[5] King Abdulaziz Univ, Jeddah 21589, Saudi Arabia
来源：
NATURE REVIEWS CANCER | 2017年 / 17卷 / 01期
基金：
美国国家卫生研究院; 新加坡国家研究基金会;
关键词：
TUMOR-ASSOCIATED MACROPHAGES; CELL LUNG-CANCER; INCORPORATING MICELLAR NANOPARTICLE; PEGYLATED LIPOSOMAL DOXORUBICIN; SYSTEMICALLY ADMINISTERED SIRNA; POLYMER HYBRID NANOPARTICLES; PATIENT-DERIVED XENOGRAFTS; PHASE-III TRIAL; DRUG-DELIVERY; BREAST-CANCER;
D O I：
10.1038/nrc.2016.108
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The intrinsic limits of conventional cancer therapies prompted the development and application of various nanotechnologies for more effective and safer cancer treatment, herein referred to as cancer nanomedicine. Considerable technological success has been achieved in this field, but the main obstacles to nanomedicine becoming a new paradigm in cancer therapy stem from the complexities and heterogeneity of tumour biology, an incomplete understanding of nano bio interactions and the challenges regarding chemistry, manufacturing and controls required for clinical translation and commercialization. This Review highlights the progress, challenges and opportunities in cancer nanomedicine and discusses novel engineering approaches that capitalize on our growing understanding of tumour biology and nano bio interactions to develop more effective nanotherapeutics for cancer patients.
引用
收藏
页码：20 / 37
页数：18
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