Human heart-type fatty acid-binding protein for on-site diagnosis of early acute myocardial infarction

被引：38

作者：

Liao, Jun ^{[1
]}

Chan, Cangel Pui-yee ^{[2
]}

Cheung, Yiu-chi ^{[2
]}

Lu, Jian-hua ^{[3
]}

Luo, Yi ^{[3
]}

Cautherley, George W. H. ^{[4
]}

Glatz, Jan F. C. ^{[5
]}

Renneberg, Reinhard ^{[2
]}

机构：

[1] Guangzhou Med Coll, Municipal Peoples Hosp Guangzhou 1, Dept Lab Sci, Guangzhou 510180, Guangdong, Peoples R China

[2] Hong Kong Univ Sci & Technol, Dept Chem, Kowloon, Hong Kong, Peoples R China

[3] Guangzhou Med Coll, Municipal Peoples Hosp Guangzhou 1, Dept Emergency, Guangzhou, Guangdong, Peoples R China

[4] R&C Biogenius Ltd, Hong Kong, Hong Kong, Peoples R China

[5] Maastricht Univ, Cardiovasc Res Inst Maastricht, Dept Mol Genet, Maastricht, Netherlands

来源：

INTERNATIONAL JOURNAL OF CARDIOLOGY | 2009年 / 133卷 / 03期

关键词：

Acute myocardial infarction; Cardiac troponin I; Creatine kinase MB; Heart-type fatty acid-binding protein; Myoglobin; PLASMA MARKER;

D O I：

10.1016/j.ijcard.2008.01.049

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Human heart-type fatty acid-binding protein (H-FABP) has a high potential as an early marker for acute myocardial infarction (AMI) being more sensitive than current routine cardiac markers. Seventy-four patients presenting to hospital with a median symptom onset of 2.2 h (IQR 1.5-2.9 h) were enrolled in this study and 54 (73%) had AMI. At presentation, H-FABP gave the highest sensitivity of 83.3% (95% CI: 70.7-92.1) and troponin I (cTnI) gave the highest specificity of 50.0% (95% CI: 27.2-72.8). This study demonstrated that H-FABP immunotest gave a better diagnostic classification at the early stage. Also, AMI was identified significantly earlier by H-FABP than cTnI (17 vs. 6 patients, p<0.05). (C) 2008 Elsevier Ireland Ltd. All rights reserved.

引用

页码：420 / 423

页数：4

共 7 条

[1]

Chan C.P.-y., 2006, IVD TECHNOLOGY, V3, P51

[2]

Chan CPY, 2004, Z KARDIOL, V93, P388, DOI 10.1007/s00392-004-0080-6

[3] Development of a quantitative lateral-flow assay for rapid detection of fatty acid-binding protein [J].

Chan, CPY ;

Sum, KW ;

Cheung, KY ;

Glatz, JFC ;

Sanderson, JE ;

Hempel, A ;

Lehmann, M ;

Renneberg, I ;

Renneberg, R .

JOURNAL OF IMMUNOLOGICAL METHODS, 2003, 279 (1-2) :91-100

[4] Early diagnosis of acute myocardial infarction using immunosensors and immunotests [J].

Chan, CPY ;

Cheng, WS ;

Glatz, JFC ;

van der Voort, D ;

Sanderson, JE ;

Hempel, A ;

Lehmann, M ;

Renneberg, I ;

Renneberg, R .

ANALYTICAL LETTERS, 2003, 36 (09) :1987-2004

[5]

GLATZ JFC, 1994, BRIT HEART J, V71, P135

[6]

Glatz JFC, 2002, J CLIN LIGAND ASSAY, V25, P167

[7] Human heart-type fatty acid-binding protein as an early diagnostic and prognostic marker in acute coronary syndrome [J].

Nakata, T ;

Hashimoto, A ;

Hase, M ;

Tsuchihashi, K ;

Shimamoto, K .

CARDIOLOGY, 2003, 99 (02) :96-104

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