Innate immune cells in asthma

被引：109

作者：

Deckers, Julie ^{[1
,2
,3
]}

Madeira, Filipe Branco ^{[1
,2
]}

Hammad, Hamida ^{[1
,2
]}

机构：

[1] DMBR VIB, Lab Immunoregulat & Mucosal Immunol, Zwijnaarde, Belgium

[2] Univ Ghent, Immunoregulat Lab, B-9000 Ghent, Belgium

[3] VIB Dept Med Prot Res, Cytokine Receptor Lab, Ghent, Belgium

来源：

TRENDS IN IMMUNOLOGY | 2013年 / 34卷 / 11期

关键词：

HOUSE-DUST MITE; ANTIGEN-PRESENTING CELLS; TRANSCRIPTION FACTOR GATA3; ALLERGIC LUNG INFLAMMATION; HUMAN MAST-CELLS; DENDRITIC CELLS; LYMPHOID-CELLS; AIRWAYS HYPERREACTIVITY; T-CELLS; HUMAN BASOPHILS;

D O I：

10.1016/j.it.2013.08.004

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Asthma is an inflammatory disease of the airways associated with a T helper (Th)2 response. Such a response in the lungs requires complex interactions between innate cells and structural cells. Dendritic cells (DCs) are pivotal during sensitization to allergens but clearly require epithelium-derived signals to become activated. Epithelial cells also contribute to the activation and the survival of mast cells (MCs), basophils, and eosinophils and group 2 innate lymphoid cells (ILC2s). In turn, these innate cells can activate DCs to sustain Th2 immunity. Here, we review the role played by these different populations of immune cells in the pathogenesis of asthma and how they interact to orchestrate Th2 immunity.

引用

页码：540 / 547

页数：8

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