Aerobic training and angiogenesis activation in patients with stable chronic heart failure: a preliminary report

被引：37

作者：

Eleuteri, Ermanno ^{[1
]}

Mezzani, Alessandro ^{[1
]}

Di Stefano, Antonino ^{[2
]}

Vallese, Davide ^{[2
]}

Gnemmi, Isabella ^{[2
]}

Delle Donne, Lorena ^{[3
]}

Taddeo, Adriano ^{[4
]}

Della Bella, Silvia ^{[5
,6
]}

Giannuzzi, Pantaleo ^{[1
]}

机构：

[1] IRCCS, Fdn Salvatore Maugeri, Div Cardiol Riabilitat, I-28010 Veruno, NO, Italy

[2] IRCCS, Fdn Salvatore Maugeri, Lab Citoimmunopatol Apparato Cardioresp, I-28010 Veruno, NO, Italy

[3] IRCCS, Fdn Salvatore Maugeri, Lab Anal Chim Clin, I-28010 Veruno, NO, Italy

[4] Deutsch Rheumaforsch Zentrum, Autoimmun Grp, Cell Biol Grp, Berlin, Germany

[5] Univ Milan, Lab Clin & Expt Immunol, Dept Med Biotechnol & Translat Med, Milan, Italy

[6] Humanitas Clin & Res Ctr, Milan, Italy

来源：

BIOMARKERS | 2013年 / 18卷 / 05期

关键词：

Cardiovascular disease; growth factors/cytokines/inflammatory mediators; sports science/exercise; ENDOTHELIAL PROGENITOR CELLS; SKELETAL-MUSCLE; GROWTH-FACTOR; EXERCISE INTOLERANCE; HYDROGEN-PEROXIDE; ANGIOPOIETIN-2; DYSFUNCTION; EXPRESSION; MECHANISMS; GUIDELINES;

D O I：

10.3109/1354750X.2013.805342

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The pathophysiology of chronic heart failure (CHF) involves multiple hystologic and molecular alterations. To determine the effects of physical training on circulating endothelial progenitor cells (EPCs), angiogenesis (angiogenin, angiopoietin-1 and -2, VEGF, Tie-2, SDF-1 alpha) and inflammation (IL-6, CRP), we compared data obtained from 11 CHF pts before and after 3 months aerobic exercise training, to those from 10 non trained CHF pts (CHF-C group, age 64+2 years, NYHA 2). At the end of the study, EPCs count and AP-2 serum levels significantly increased in the CHF-TR group. These preliminary data suggest a significant effect of even a short program of physical training on angiogenic activation and endothelial dysfunction.

引用

页码：418 / 424

页数：7

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