Aerobic training and angiogenesis activation in patients with stable chronic heart failure: a preliminary report

被引：35
作者：
Eleuteri, Ermanno [1 ]
Mezzani, Alessandro [1 ]
Di Stefano, Antonino [2 ]
Vallese, Davide [2 ]
Gnemmi, Isabella [2 ]
Delle Donne, Lorena [3 ]
Taddeo, Adriano [4 ]
Della Bella, Silvia [5 ,6 ]
Giannuzzi, Pantaleo [1 ]
机构：
[1] IRCCS, Fdn Salvatore Maugeri, Div Cardiol Riabilitat, I-28010 Veruno, NO, Italy
[2] IRCCS, Fdn Salvatore Maugeri, Lab Citoimmunopatol Apparato Cardioresp, I-28010 Veruno, NO, Italy
[3] IRCCS, Fdn Salvatore Maugeri, Lab Anal Chim Clin, I-28010 Veruno, NO, Italy
[4] Deutsch Rheumaforsch Zentrum, Autoimmun Grp, Cell Biol Grp, Berlin, Germany
[5] Univ Milan, Lab Clin & Expt Immunol, Dept Med Biotechnol & Translat Med, Milan, Italy
[6] Humanitas Clin & Res Ctr, Milan, Italy
来源：
BIOMARKERS | 2013年 / 18卷 / 05期
关键词：
Cardiovascular disease; growth factors/cytokines/inflammatory mediators; sports science/exercise; ENDOTHELIAL PROGENITOR CELLS; SKELETAL-MUSCLE; GROWTH-FACTOR; EXERCISE INTOLERANCE; HYDROGEN-PEROXIDE; ANGIOPOIETIN-2; DYSFUNCTION; EXPRESSION; MECHANISMS; GUIDELINES;
D O I：
10.3109/1354750X.2013.805342
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
The pathophysiology of chronic heart failure (CHF) involves multiple hystologic and molecular alterations. To determine the effects of physical training on circulating endothelial progenitor cells (EPCs), angiogenesis (angiogenin, angiopoietin-1 and -2, VEGF, Tie-2, SDF-1 alpha) and inflammation (IL-6, CRP), we compared data obtained from 11 CHF pts before and after 3 months aerobic exercise training, to those from 10 non trained CHF pts (CHF-C group, age 64+2 years, NYHA 2). At the end of the study, EPCs count and AP-2 serum levels significantly increased in the CHF-TR group. These preliminary data suggest a significant effect of even a short program of physical training on angiogenic activation and endothelial dysfunction.
引用
收藏
页码：418 / 424
页数：7
相关论文
共 40 条
  • [1] Physical training modulates proinflammatory cytokines and the soluble Fas/soluble Fas ligand system in patients with chronic heart failure
    Adamopoulos, S
    Parissis, J
    Karatzas, D
    Kroupis, C
    Georgiadis, M
    Karavolias, G
    Paraskevaidis, J
    Koniavitou, K
    Coats, AJS
    Kremastinos, DT
    [J]. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2002, 39 (04) : 653 - 663
  • [2] Induction of iNOS expression in skeletal muscle by IL-1β and NFκB activation:: an in vitro and in vivo study
    Adams, V
    Nehrhoff, B
    Späte, U
    Linke, A
    Schulze, PC
    Baur, A
    Gielen, S
    Hambrecht, R
    Schuler, G
    [J]. CARDIOVASCULAR RESEARCH, 2002, 54 (01) : 95 - 104
  • [3] [Anonymous], 2005, NORMAL VALUES
  • [4] Isolation of putative progenitor endothelial cells for angiogenesis
    Asahara, T
    Murohara, T
    Sullivan, A
    Silver, M
    vanderZee, R
    Li, T
    Witzenbichler, B
    Schatteman, G
    Isner, JM
    [J]. SCIENCE, 1997, 275 (5302) : 964 - 967
  • [5] BRADLEY JR, 1993, AM J PATHOL, V142, P1598
  • [6] Hydrogen peroxide regulation of endothelial function: Origins, mechanisms, and consequences
    Cai, H
    [J]. CARDIOVASCULAR RESEARCH, 2005, 68 (01) : 26 - 36
  • [7] Endothelial dysfunction in cardiovascular diseases - The role of oxidant stress
    Cai, H
    Harrison, DG
    [J]. CIRCULATION RESEARCH, 2000, 87 (10) : 840 - 844
  • [8] Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1
    Ceradini, DJ
    Kulkarni, AR
    Callaghan, MJ
    Tepper, OM
    Bastidas, N
    Kleinman, ME
    Capla, JM
    Galiano, RD
    Levine, JP
    Gurtner, GC
    [J]. NATURE MEDICINE, 2004, 10 (08) : 858 - 864
  • [9] Plasma angiopoietin-1, angiopoietin-2, and angiopoietin receptor tie-2 levels in congestive heart failure
    Chong, AY
    Caine, GJ
    Freestone, B
    Blann, AD
    Lip, GYH
    [J]. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2004, 43 (03) : 423 - 428
  • [10] Fast reduction of peripheral blood endothelial progenitor cells in healthy humans exposed to acute systemic hypoxia
    Colombo, Elena
    Marconi, Claudio
    Taddeo, Adriano
    Cappelletti, Monica
    Villa, Maria Luisa
    Marzorati, Mauro
    Porcelli, Simone
    Vezzoli, Alessandra
    Della Bella, Silvia
    [J]. JOURNAL OF PHYSIOLOGY-LONDON, 2012, 590 (03): : 519 - 531
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