Effect of Zwitterionic Polymers on Wound Healing

被引:37
作者
Fujishita, Shigeto [1 ,3 ]
Inaba, Chika [1 ]
Tada, Susumu [1 ]
Gemmei-Ide, Makoto [1 ]
Kitano, Hiromi [1 ]
Saruwatari, Yoshiyuki [2 ]
机构
[1] Toyama Univ, Grad Sch Sci & Engn, Dept Appl Chem, Toyama 9308555, Japan
[2] Osaka Organ Chem Ind Ltd, R&D Lab, Kashiwara 5820020, Japan
[3] Teika Pharmaceut Co Ltd, Toyama 9300982, Japan
基金
日本学术振兴会;
关键词
wound healing; zwitterionic polymer; full-thickness excisional wound; protein adsorption; neutrophile adhesion;
D O I
10.1248/bpb.31.2309
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The effect of a thin film of a zwitterionic random copolymer composed of carboxybetaine [1-carboxy-N,N-dimethyl-N-(2'-methacryloyloxyethyl) methanaminium inner salt] (CMB) and n-butyl methacrylate (BMA), poly(CMB-r-BMA) (CMB, 30 mol%), on the healing of a full-thickness excisional and incisional wound in hairless rats was examined. The poly(CMB-r-BMA) film significantly enhanced wound closure and complete healing of a full-thickness excisional wound compared with the effect of the poly(n-butyl methacrylate) (PBMA) and the poly(ethylene terephthalate) (PET) films. However, the poly(CMB-r-BMA) film did not enhance healing of a full-thickness incisional wound in hairless rats. The amount of proteins adsorbed and that of neutrophiles adhered onto the poly(CMB-r-BMA) film were significantly smaller than those onto the PBMA and PET films. The results suggested that various cells and growth factors in the wound exudate are utilized effectively by covering an excisional wound with the poly(CMB-r-BMA) film, resulting in acceleration of healing. In addition, the poly(CMB-r-BMA) film significantly enhanced healing of a full-thickness excisional wound in hairless rats compared with the effect of Tegaderm (R) as wound dressings. The poly(CMB-r-BMA) film has potential as a new wound dressing.
引用
收藏
页码:2309 / 2315
页数:7
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