Diastereoselective synthesis of pyrrolidine derivatives via a one-pot nitro-Mannich/hydroamination cascade using base and gold catalysis

被引：19

作者：

Duris, Andrej ^{[1
]}

Barber, David M. ^{[1
]}

Sanganee, Hitesh J. ^{[2
]}

Dixon, Darren J. ^{[1
]}

机构：

[1] Univ Oxford, Chem Res Lab, Dept Chem, Oxford OX1 3TA, England

[2] AstraZeneca R&D, New Opportun iMed, Alderley Pk SK10 4GT, Cheshire, England

来源：

CHEMICAL COMMUNICATIONS | 2013年 / 49卷 / 27期

基金：

英国工程与自然科学研究理事会;

关键词：

INTRAMOLECULAR HYDROAMINATION; INTERMOLECULAR HYDROAMINATION; ENANTIOSELECTIVE SYNTHESIS; STEREOSELECTIVE-SYNTHESIS; AZOMETHINE YLIDES; ATOM ECONOMY; ALLENES; (-)-NAKADOMARIN; REPLACEMENT; METATHESIS;

D O I：

10.1039/c3cc40729b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An efficient one-pot nitro-Mannich/hydroamination cascade reaction for the synthesis of substituted pyrrolidines bearing three stereocentres is reported. Proceeding under the control of a combination of base and gold(I) catalysts, the cascade reaction affords the pyrrolidine products in high yields with good to excellent diastereoselectivities.

引用

页码：2777 / 2779

页数：3

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