Are Thiopurines and Anti-TNFα Agents Safe to Use in Pregnant Patients With Inflammatory Bowel Disease?

被引：2
作者：
Sheibani, Sarah [1 ]
Mahadevan, Uma [1 ]
机构：
[1] UCSF Ctr Colitis & Crohns Dis, San Francisco, CA 94115 USA
来源：
AMERICAN JOURNAL OF GASTROENTEROLOGY | 2013年 / 108卷 / 03期
关键词：
CROHNS-DISEASE; BIRTH OUTCOMES; WOMEN; INFLIXIMAB;
D O I：
10.1038/ajg.2012.436
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Inflammatory bowel disease affects women in their peak reproductive years. Increased disease activity during pregnancy has been associated with adverse outcomes. Thus, it is recommended that immunosuppressant medications be continued during pregnancy. However, data regarding the safety of these medications during pregnancy are sparse and often conflicting. The study by Casanova et al. (1) adds to the growing evidence that the use of thiopurines and anti-TNF alpha agents during pregnancy does not increase the risk of birth defects. Results from prospective studies with longer follow-up are needed to fully understand the impact of thiopurines and anti-TNF alpha agents on child development and maturation of the immune system. Am J Gastroenterol 2013; 108:441-443; doi:10.1038/ajg.2012.436
引用
收藏
页码：441 / 443
页数：3
相关论文
共 21 条
  • [1] Akbari B, 2012, INFLAMM BOWEL DIS
  • [2] Bush M C, 2004, J Matern Fetal Neonatal Med, V15, P237, DOI 10.1080/14767050410001668662
  • [3] A Safety Assessment of Tumor Necrosis Factor Antagonists During Pregnancy: A Review of the Food and Drug Administration Database
    Carter, John D.
    Ladhani, Anil
    Ricca, Louis R.
    Valeriano, Joanne
    Vasey, Frank B.
    [J]. JOURNAL OF RHEUMATOLOGY, 2009, 36 (03) : 635 - 641
  • [4] Safety of Thiopurines and Anti-TNF-α Drugs During Pregnancy in Patients With Inflammatory Bowel Disease
    Casanova, M. J.
    Chaparro, M.
    Domenech, E.
    Barreiro-de Acosta, M.
    Bermejo, F.
    Iglesias, E.
    Gomollon, F.
    Rodrigo, L.
    Calvet, X.
    Esteve, M.
    Garcia-Planella, E.
    Garcia-Lopez, S.
    Taxonera, C.
    Calvo, M.
    Lopez, M.
    Ginard, D.
    Gomez-Garcia, M.
    Garrido, E.
    Perez-Calle, J. L.
    Beltran, B.
    Piqueras, M.
    Saro, C.
    Botella, B.
    Duenas, C.
    Ponferrada, A.
    Manosa, M.
    Garcia-Sanchez, V.
    Mate, J.
    Gisbert, J. P.
    [J]. AMERICAN JOURNAL OF GASTROENTEROLOGY, 2013, 108 (03) : 433 - 440
  • [5] Outcome of pregnancy in women receiving infliximab for the treatment of Crohn's disease and rheumatoid arthritis
    Katz, JA
    Antoni, C
    Keenan, GE
    Smith, DE
    Jacobs, SJ
    Lichtenstein, GR
    [J]. AMERICAN JOURNAL OF GASTROENTEROLOGY, 2004, 99 (12) : 2385 - 2392
  • [6] Epidemiology of inflammatory bowel disease
    Loftus, EV
    Sandborn, WJ
    [J]. GASTROENTEROLOGY CLINICS OF NORTH AMERICA, 2002, 31 (01) : 1 - +
  • [7] Intentional infliximab use during pregnancy for induction or maintenance of remission in Crohn's disease
    Mahadevan, U
    Kane, S
    Sandborn, WJ
    Cohen, RD
    Hanson, K
    Terdiman, JP
    Binion, DG
    [J]. ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 2005, 21 (06) : 733 - 738
  • [8] Mahadevan U, 2012, CLIN GASTROENTEROL H
  • [9] Mahadevan U, PIANO 1000 PATIENT P
  • [10] Pregnancy outcomes in women with inflammatory bowel disease: A large community-based study from Northern California
    Mahadevan, Uma
    Sandborn, William J.
    Li, De-Kun
    Hakimian, Shahbaz
    Kane, Sunanda
    Corley, Douglas A.
    [J]. GASTROENTEROLOGY, 2007, 133 (04) : 1106 - 1112
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