Alcoholic pancreatitis

被引：27

作者：

Schneider, A ^{[1
]}

Singer, MV ^{[1
]}

机构：

[1] Heidelberg Univ, Univ Hosp Mannheim, Dept Med Gastroenterol Hepatol Infect Dis 2, D-6800 Mannheim, Germany

来源：

DIGESTIVE DISEASES | 2005年 / 23卷 / 3-4期

关键词：

pancreatitis; alcoholic; alcohol consumption; pancreatic damage; alcohol-induced;

D O I：

10.1159/000090169

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

A history of excessive alcohol consumption is found in the majority of patients with chronic pancreatitis, and numerous research efforts revealed insights into the pathogenesis of alcohol-induced pancreatic damage. However, the exact mechanisms underlying the disease are not yet clarified, and the origin of alcoholic chronic pancreatitis continues to be the topic of speculation and investigation. This article provides an overview about the epidemiology of alcoholic chronic pancreatitis, the epidemiologic association of alcohol intake and pancreatitis and the clinical course of the disease. Finally, this article summarizes several hypothetical concepts that try to explain the early and late pathophysiological mechanisms of acute and chronic pancreatitis. Copyright (C) 2005 S. Karger AG, Basel.

引用

页码：222 / 231

页数：10

共 83 条

[51]

MARKS I. N., 1963, S AFRICAN MED JOUR, V37, P1039

[52] A review: Acute and chronic effects of ethanol and alcoholic beverages on the pancreatic exocrine secretion in vivo and in vitro [J].

Niebergall-Roth, E ;

Harder, H ;

Singer, MV .

ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH, 1998, 22 (07) :1570-1583

[53]

NORONHA M, 1983, Z GASTROENTEROL, V21, P666

[54] Chronic ethanol administration causes oxidative stress in the rat pancreas [J].

Norton, ID ;

Apte, MV ;

Lux, O ;

Haber, PS ;

Pirola, RC ;

Wilson, JS .

JOURNAL OF LABORATORY AND CLINICAL MEDICINE, 1998, 131 (05) :442-446

[55] A mouse model of ethanol dependent pancreatic fibrosis [J].

Perides, G ;

Tao, X ;

West, N ;

Sharma, A ;

Steer, ML .

GUT, 2005, 54 (10) :1461-1467

[56] SPINK1/PSTI polymorphisms act as disease modifiers in familial and idiopathic chronic pancreatitis [J].

Pfützer, RH ;

Barmada, MM ;

Brunskill, APJ ;

Finch, R ;

Hart, PS ;

Neoptolemos, J ;

Furey, WF ;

Whitcomb, DC .

GASTROENTEROLOGY, 2000, 119 (03) :615-623

[57] Pancreatic cholesterol esterase, ES-10, and fatty acid ethyl ester synthase III gene expression are increased in the pancreas and liver but not in the brain or heart with long-term ethanol feeding in rats [J].

Pfützer, RH ;

Tadic, SD ;

Li, HS ;

Thompson, BS ;

Zhang, JY ;

Ford, ME ;

Eagon, PK ;

Whitcomb, DC .

PANCREAS, 2002, 25 (01) :101-+

[58]

PITCHUMONI CS, 1984, AM J GASTROENTEROL, V79, P382

[59] DEATH DUE TO ACUTE-PANCREATITIS - A RETROSPECTIVE ANALYSIS OF 405 AUTOPSY CASES [J].

RENNER, IG ;

SAVAGE, WT ;

PANTOJA, JL ;

RENNER, VJ .

DIGESTIVE DISEASES AND SCIENCES, 1985, 30 (10) :1005-1018

[60]

SARLES H, 1989, ANNU REV MED, V40, P453

← 1 2 3 4 5 6 7 8 9 →