Association of Chromosome 9p21 Genetic Variants with Risk of Coronary Heart Disease in the East Asian Population: A Meta-Analysis

被引：7

作者：

Dong, Liping ^{[1
]}

Wang, Haoran ^{[2
]}

Wang, Dao Wen ^{[2
]}

Ding, Hu ^{[2
]}

机构：

[1] Huazhong Univ Sci & Technol, Tongji Med Coll, Puai Hosp, Dept Nephrol, Wuhan 430030, Peoples R China

[2] Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Dept Internal Med, Wuhan 430030, Peoples R China

来源：

ANNALS OF HUMAN GENETICS | 2013年 / 77卷

关键词：

9p21; East Asian; coronary heart disease; meta-analysis; GENOME-WIDE ASSOCIATION; MYOCARDIAL-INFARCTION; ARTERY-DISEASE; SUSCEPTIBILITY LOCUS; ISCHEMIC-STROKE; COMMON VARIANT; POLYMORPHISM; REPLICATION; PROGRESSION; JAPANESE;

D O I：

10.1111/ahg.12010

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Our aim was to evaluate the effect of SNPs in the 9p21 locus on genetic susceptibility of coronary heart disease in the East Asian population. We searched PubMed, EMBASE and CNKI for publications relating to the association between SNPs within the 9p21 locus and coronary heart disease in the East Asian population. This meta-analysis was assessed by STATA 9.2. Twenty-one studies from 15 eligible papers composing 25,945 cases and 31,777 control subjects were included in the meta-analysis. The odds ratio (OR) and 95% confidence interval (CI) for the risk allele was 1.30 (1.251.35) with moderate heterogeneity. No publication bias was observed in this study. Sensitivity analysis further strengthened the validity of this association. In conclusion, SNPs within the 9p21 locus were strongly associated with the risk of coronary heart disease in the East Asian population with a similar risk OR to the Caucasian population.

引用

页码：183 / 190

页数：8

共 42 条

[11] The Effect of Chromosome 9p21 Variants on Cardiovascular Disease May Be Modified by Dietary Intake: Evidence from a Case/Control and a Prospective Study [J].

Do, Ron ;

Xie, Changchun ;

Zhang, Xiaohe ;

Mannisto, Satu ;

Harald, Kennet ;

Islam, Shofiqul ;

Bailey, Swneke D. ;

Rangarajan, Sumathy ;

McQueen, Matthew J. ;

Diaz, Rafael ;

Liu Lisheng ;

Wang, Xingyu ;

Silander, Kaisa ;

Peltonen, Leena ;

Yusuf, Salim ;

Salomaa, Veikko ;

Engert, James C. ;

Anand, Sonia S. .

PLOS MEDICINE, 2011, 8 (10)

[12]

Guo Jin Guo Jin, 2011, Academic Journal of Second Military Medical University, V32, P822

[13] The same sequence variant on 9p21 associates with myocardial infarction, abdominal aortic aneurysm and intracranial aneurysm [J].

Helgadottir, Anna ;

Thorleifsson, Gudmar ;

Magnusson, Kristinn P. ;

Gretarsdottir, Solveig ;

Steinthorsdottir, Valgerdur ;

Manolescu, Andrei ;

Jones, Gregory T. ;

Rinkel, Gabriel J. E. ;

Blankensteijn, Jan D. ;

Ronkainen, Antti ;

Jaaskelainen, Juha E. ;

Kyo, Yoshiki ;

Lenk, Guy M. ;

Sakalihasan, Natzi ;

Kostulas, Konstantinos ;

Gottsater, Anders ;

Flex, Andrea ;

Stefansson, Hreinn ;

Hansen, Torben ;

Andersen, Gitte ;

Weinsheimer, Shantel ;

Borch-Johnsen, Knut ;

Jorgensen, Torben ;

Shah, Svati H. ;

Quyyumi, Arshed A. ;

Granger, Christopher B. ;

Reilly, Muredach P. ;

Austin, Harland ;

Levey, Allan I. ;

Vaccarino, Viola ;

Palsdottir, Ebba ;

Walters, G. Bragi ;

Jonsdottir, Thorbjorg ;

Snorradottir, Steinunn ;

Magnusdottir, Dana ;

Gudmundsson, Gudmundur ;

Ferrell, Robert E. ;

Sveinbjornsdottir, Sigurlaug ;

Hernesniemi, Juha ;

Niemela, Mika ;

Limet, Raymond ;

Andersen, Karl ;

Sigurdsson, Gunnar ;

Benediktsson, Rafn ;

Verhoeven, Eric L. G. ;

Teijink, Joep A. W. ;

Grobbee, Diederick E. ;

Rader, Daniel J. ;

Collier, David A. ;

Pedersen, Oluf .

NATURE GENETICS, 2008, 40 (02) :217-224

[14] A common variant on chromosome 9p21 affects the risk of myocardial infarction [J].

Helgadottir, Anna ;

Thorleifsson, Gudmar ;

Manolescu, Andrei ;

Gretarsdottir, Solveig ;

Blondal, Thorarinn ;

Jonasdottir, Aslaug ;

Jonasdottir, Adalbjorg ;

Sigurdsson, Asgeir ;

Baker, Adam ;

Palsson, Arnar ;

Masson, Gisli ;

Gudbjartsson, Daniel F. ;

Magnusson, Kristinn P. ;

Andersen, Karl ;

Levey, Allan I. ;

Backman, Valgerdur M. ;

Matthiasdottir, Sigurborg ;

Jonsdottir, Thorbjorg ;

Palsson, Stefan ;

Einarsdottir, Helga ;

Gunnarsdottir, Steinunn ;

Gylfason, Arnaldur ;

Vaccarino, Viola ;

Hooper, W. Craig ;

Reilly, Muredach P. ;

Granger, Christopher B. ;

Austin, Harland ;

Rader, Daniel J. ;

Shah, Svati H. ;

Quyyumi, Arshed A. ;

Gulcher, Jeffrey R. ;

Thorgeirsson, Gudmundur ;

Thorsteinsdottir, Unnur ;

Kong, Augustine ;

Stefansson, Kari .

SCIENCE, 2007, 316 (5830) :1491-1493

[15] Measuring inconsistency in meta-analyses [J].

Higgins, JPT ;

Thompson, SG ;

Deeks, JJ ;

Altman, DG .

BMJ-BRITISH MEDICAL JOURNAL, 2003, 327 (7414) :557-560

[16] Replication of the association between a chromosome 9p21 polymorphism and coronary artery disease in Japanese and Korean populations [J].

Hinohara, Kunihiko ;

Nakajima, Toshiaki ;

Takahashi, Megumi ;

Hohda, Shigeru ;

Sasaoka, Taishi ;

Nakahara, Ken-ichi ;

Chida, Kouji ;

Sawabe, Motoji ;

Arimura, Takuro ;

Sato, Akinori ;

Lee, Bok-Soo ;

Ban, Ji-min ;

Yasunami, Michio ;

Park, Jeong-Euy ;

Izumi, Toru ;

Kimura, Akinori .

JOURNAL OF HUMAN GENETICS, 2008, 53 (04) :357-359

[17] Validation of the association of genetic variants on chromosome 9p21 and 1q41 with myocardial infarction in a Japanese population [J].

Hiura, Yumiko ;

Fukushima, Yasue ;

Yuno, Miyuki ;

Sawamura, Hiromi ;

Kokubo, Yoshihiro ;

Okamura, Tomonori ;

Tomoike, Hitonobu ;

Goto, Yoichi ;

Nonogi, Hiroshi ;

Takahashi, Rie ;

Iwai, Naoharu .

CIRCULATION JOURNAL, 2008, 72 (08) :1213-1217

[18]

Lin HF, 2011, J INVEST MED, V59, P926, DOI 10.2310/JIM.0b013e318214ea49

[19] Sex Differential Genetic Effect of Chromosome 9p21 on Subclinical Atherosclerosis [J].

Lin, Hsiu-Fen ;

Tsai, Pei-Chien ;

Lin, Ruey-Tay ;

Khor, Gim-Thean ;

Sheu, Sheng-Hsiung ;

Juo, Suh-Hang Hank .

PLOS ONE, 2010, 5 (11)

[20] Genome-wide association study in Han Chinese identifies four new susceptibility loci for coronary artery disease [J].

Lu, Xiangfeng ;

Wang, Laiyuan ;

Chen, Shufeng ;

He, Lin ;

Yang, Xueli ;

Shi, Yongyong ;

Cheng, Jing ;

Zhang, Liang ;

Gu, C. Charles ;

Huang, Jianfeng ;

Wu, Tangchun ;

Ma, Yitong ;

Li, Jianxin ;

Cao, Jie ;

Chen, Jichun ;

Ge, Dongliang ;

Fan, Zhongjie ;

Li, Ying ;

Zhao, Liancheng ;

Li, Hongfan ;

Zhou, Xiaoyang ;

Chen, Lanying ;

Liu, Donghua ;

Chen, Jingping ;

Duan, Xiufang ;

Hao, Yongchen ;

Wang, Ligui ;

Lu, Fanghong ;

Liu, Zhendong ;

Yao, Cailiang ;

Shen, Chong ;

Pu, Xiaodong ;

Yu, Lin ;

Fang, Xianghua ;

Xu, Lihua ;

Mu, Jianjun ;

Wu, Xianping ;

Zheng, Runping ;

Wu, Naqiong ;

Zhao, Qi ;

Li, Yun ;

Liu, Xiaoli ;

Wang, Mengqin ;

Yu, Dahai ;

Hu, Dongsheng ;

Ji, Xu ;

Guo, Dongshuang ;

Sun, Dongling ;

Wang, Qianqian ;

Yang, Ying .

NATURE GENETICS, 2012, 44 (08) :890-+

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