The Mechanism of Tissue-Restricted Antigen Gene Expression by AIRE

被引：26
作者：
Zumer, Kristina [1 ]
Saksela, Kalle [1 ]
Peterlin, B. Matija [1 ,2 ]
机构：
[1] Univ Helsinki, Helsinki Univ Cent Hosp, Haartman Inst, Dept Virol, FIN-00014 Helsinki, Finland
[2] Univ Calif San Francisco, Rosalind Russell Med Res Ctr, Dept Med, San Francisco, CA 94143 USA
来源：
JOURNAL OF IMMUNOLOGY | 2013年 / 190卷 / 06期
关键词：
THYMIC EPITHELIAL-CELLS; CANDIDIASIS-ECTODERMAL DYSTROPHY; AUTOIMMUNE REGULATOR PROTEIN; P-TEFB; RNA-POLYMERASE; DNA-PK; TRANSCRIPTIONAL ELONGATION; IMMUNOLOGICAL-TOLERANCE; FUNCTIONAL DOMAINS; BINDING-PROTEIN;
D O I：
10.4049/jimmunol.1203210
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The autoimmune regulator is a critical transcription factor for generating central tolerance in the thymus. Recent studies have revealed how the autoimmune regulator targets many otherwise tissue-restricted Ag genes to enable negative selection of autoreactive T cells. The Journal of Immunology, 2013, 190: 2479-2482.
引用
收藏
页码：2479 / 2482
页数：4
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