Endothelium-derived epoxyeicosatrienoic acids and vascular function

被引：115
作者：
Fleming, I [1 ]
Busse, R [1 ]
机构：
[1] Goethe Univ Frankfurt, Vasc Signalling Grp, Inst Kardiovaskulare Physiol, D-60590 Frankfurt, Germany
来源：
HYPERTENSION | 2006年 / 47卷 / 04期
关键词：
calcium channels; endothelium-derived factors; hypertension; vasodilatation;
D O I：
10.1161/01.HYP.0000208597.87957.89
中图分类号：
R6 [外科学];
学科分类号：
1002 ; 100210 ;
摘要：
Epoxyeicosatrienoic acids ( EETs) are epoxides of arachidonic acid generated by cytochrome P450 ( CYP) epoxygenases. The activation of CYP epoxygenases in endothelial cells is an important step in the NO and prostacyclin-independent vasodilatation of several vascular beds, and EETs have been identified as an endothelium-derived hyperpolarizing factor. However, EETs also exert membrane potential-independent effects and modulate several signaling cascades that affect endothelial cell proliferation and angiogenesis. This review summarizes the role of CYP-derived EETs in endothelium-derived hyperpolarizing factor-mediated responses and highlights the evidence indicating that EETs are important second messengers involved in endothelial cell signaling pathways related to angiogenesis.
引用
收藏
页码：629 / 633
页数：5
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