Comment on "Restoring Voluntary Control of Locomotion After Paralyzing Spinal Cord Injury"

被引:17
作者
Slawinska, Urszula [2 ]
Rossignol, Serge [3 ]
Bennett, David J. [4 ]
Schmidt, Brian J. [1 ]
Frigon, Alain [5 ]
Fouad, Karim [6 ]
Jordan, Larry M. [1 ]
机构
[1] Univ Manitoba, Dept Physiol, Spinal Cord Res Ctr, Winnipeg, MB, Canada
[2] M Nencki Inst Expt Biol, Dept Neurophysiol, PL-02093 Warsaw, Poland
[3] Univ Montreal, Fac Med, Grp Rech Syst Nerveux Cent Pavillon Desmarais, Montreal, PQ H3C 3J7, Canada
[4] Univ Alberta, Ctr Neurosci, Edmonton, AB, Canada
[5] Univ Sherbrooke, Dept Physiol & Biophys, Fac Med & Hlth Sci, Sherbrooke, PQ J1K 2R1, Canada
[6] Univ Alberta, Fac Rehabil Med, Edmonton, AB, Canada
关键词
PROPRIOSPINAL NEURONS; COMMAND SIGNAL; BULBOSPINAL TRANSMISSION; CONSTITUTIVE ACTIVITY; RECEPTORS; RECOVERY; DEPENDS; PATTERN;
D O I
10.1126/science.1226082
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Van den Brand et al. (Reports, 1 June 2012, p. 1182) claim to have restored voluntary control of locomotion after paralyzing spinal cord injury. They have not considered recent findings that their upright posture paradigm contributes to locomotor capability after such injuries. We propose that postural adjustments that activate the locomotor central pattern generator in the upright posture, rather than direct voluntary control of locomotion, account for their results.
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页数:2
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