Lipid Droplet-Targetable Fluorescence Guided Photodynamic Therapy of Cancer Cells with an Activatable AIE-Active Fluorescent Probe for Hydrogen Peroxide

被引：68

作者：

Jiang, Guoyu ^{[1
,2
]}

Li, Chunbin ^{[1
]}

Liu, Xiang ^{[2
]}

Chen, Qingqing ^{[2
]}

Li, Xiaokang ^{[2
]}

Gu, Xinggui ^{[3
]}

Zhang, Pengfei ^{[4
]}

Lai, Qingfang ^{[2
]}

Wang, Jianguo ^{[1
,2
]}

机构：

[1] Inner Mongolia Univ, Coll Chem & Chem Engn, Inner Mongolia Key Lab Fine Organ Synth, Hohhot 010021, Peoples R China

[2] Gannan Normal Univ, Key Lab Organopharmaceut Chem, Ganzhou 341000, Peoples R China

[3] Beijing Univ Chem Technol, Beijing Adv Innovat Ctr Soft Matter Sci & Engn, Beijing 100029, Peoples R China

[4] Chinese Acad Sci, Inst Biomed & Biotechnol, Shenzhen Inst Adv Technol,Shenzhen Bioact Mat Eng, Guangdong Key Lab Nanomed,CAS Key Lab Hlth Inform, Shenzhen 518055, Peoples R China

来源：

ADVANCED OPTICAL MATERIALS | 2020年 / 8卷 / 20期

基金：

中国国家自然科学基金;

关键词：

aggregation-induced emission; fluorescence imaging; hydrogen peroxide; lipid droplet-targeting; photodynamic therapy; AGGREGATION-INDUCED EMISSION; IN-VIVO; NANOPARTICLES; PHOTOSENSITIZER; LUMINOGENS; ORGANELLES; VITRO;

D O I：

10.1002/adom.202001119

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

Fluorescence guided photodynamic therapy (FL-PDT) offers the great opportunity for realizing personalized medicine in the treatment of cancer. Aggregation-induced emission luminogens (AIEgens) with efficient emission and reactive oxygen species (ROS) generation even in the aggregated state are the ideal FL-PDT photosensitizers to overcome the quenched fluorescence and ROS that traditional photosensitizers faced in PDT. Moreover, considering the higher levels of H(2)O(2)in cancer cells than in normal cells and the fact that lipid droplet (LD) accumulation correlates to the enhanced survival rate of cancer cells in hypoxic conditions, it will be very interesting and rewarding to develop a LD-targeted, H(2)O(2)activatable AIE-active photosensitizer for FL-PDT. Thereafter, a LD-targeted fluorescent probe TPECNPB is fabricated for H2O2-activatable fluorescence guided PDT of cancer cells. AIE-active TPECNPB exhibits the unique features of large Stokes shift (175 nm), superior photostability, and excellent selectivity toward H2O2. TPECNPB is able to selectively accumulate in LD and is activated by endogenous H(2)O(2)for light-up bioimaging in live MCF-7 cells. In addition, H2O2-activatable singlet oxygen generation and PDT of cancer cells has also been successfully implemented with TPECNPB. These prominent parameters would make TPECNPB a powerful toolbox for H2O2-activatable and LD-targetable fluorescence guided PDT of cancer cells.

引用

页数：8

共 61 条

[1] Aggregation-induced emission nanoparticles as photosensitizer for two-photon photodynamic therapy [J].

Alifu, Nuernisha ;

Dong, Xiaobiao ;

Li, Dongyu ;

Sun, Xianhe ;

Zebibula, Abudureheman ;

Zhang, Deqing ;

Zhang, Guanxin ;

Qian, Jun .

MATERIALS CHEMISTRY FRONTIERS, 2017, 1 (09) :1746-1753

[2] Antioxidant Role for Lipid Droplets in a Stem Cell Niche of Drosophila [J].

Bailey, Andrew P. ;

Koster, Grielof ;

Guillermier, Christelle ;

Hirst, Elizabeth M. A. ;

MacRae, James I. ;

Lechene, Claude P. ;

Postle, Anthony D. ;

Gould, Alex P. .

CELL, 2015, 163 (02) :340-353

[3] SINGLET OXYGEN FORMATION IN MONOMERIC AND AGGREGATED PORPHYRIN-C [J].

BENNETT, LE ;

GHIGGINO, KP ;

HENDERSON, RW .

JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY, 1989, 3 (01) :81-89

[4] Regulating the Photophysical Property of Organic/Polymer Optical Agents for Promoted Cancer Phototheranostics [J].

Chen, Chao ;

Ou, Hanlin ;

Liu, Ruihua ;

Ding, Dan .

ADVANCED MATERIALS, 2020, 32 (03)

[5] An Amorphous Nickel-Iron-Based Electrocatalyst with Unusual Local Structures for Ultrafast Oxygen Evolution Reaction [J].

Chen, Gao ;

Zhu, Yapping ;

Chen, Hao Ming ;

Hu, Zhiwei ;

Hung, Sung-Fu ;

Ma, Nana ;

Dai, Jie ;

Lin, Hong-Ji ;

Chen, Chien-Te ;

Zhou, Wei ;

Shao, Zongping .

ADVANCED MATERIALS, 2019, 31 (28)

[6]

Chen MF, 2018, MOLECULES, V24

[7] Evoking Photothermy by Capturing Intramolecular Bond Stretching Vibration-Induced Dark-State Energy [J].

Chen, Ming ;

Zhang, Xiaoyan ;

Liu, Junkai ;

Liu, Feng ;

Zhang, Ruoyao ;

Wei, Peifa ;

Feng, Haitao ;

Tu, Mei ;

Qin, Anjun ;

Lam, Jacky W. Y. ;

Ding, Dan ;

Tang, Ben Zhong .

ACS NANO, 2020, 14 (04) :4265-4275

[8] Mitochondria-Targeted Polydopamine Nanocomposite with AIE Photosensitizer for Image-Guided Photodynamic and Photothermal Tumor Ablation [J].

Chen, Yuzhi ;

Ai, Wenting ;

Guo, Xuan ;

Li, Yawen ;

Ma, Yufan ;

Chen, Lifang ;

Zhang, Hui ;

Wang, Tongxin ;

Zhang, Xin ;

Wang, Zhuo .

SMALL, 2019, 15 (30)

[9] A Fluorescent Probe for Hydrogen Peroxide in Vivo Based on the Modulation of Intramolecular Charge Transfer [J].

Chen, Yuzhi ;

Shi, Xiaomin ;

Lu, Zhengliang ;

Wang, Xuefei ;

Wang, Zhuo .

ANALYTICAL CHEMISTRY, 2017, 89 (10) :5278-5284

[10] Photodynamic therapy for cancer [J].

Dolmans, DEJGJ ;

Fukumura, D ;

Jain, RK .

NATURE REVIEWS CANCER, 2003, 3 (05) :380-387

← 1 2 3 4 5 6 7 →