Neurotropic virus tracing suggests a membranous-coating-mediated mechanism for transsynaptic communication

被引：111

作者：

Li, Yan-Chao ^{[1
,2
]}

Bai, Wan-Zhu ^{[2
,3
]}

Hirano, Norio ^{[4
]}

Hayashida, Tsuyako ^{[2
]}

Taniguchi, Takahide ^{[5
]}

Sugita, Yoichi ^{[6
,7
]}

Tohyama, Koujiro ^{[2
,8
]}

Hashikawa, Tsutomu ^{[2
,7
]}

机构：

[1] Jilin Univ, Norman Bethune Coll Med, Dept Histol & Embryol, Changchun 130021, Jilin Province, Peoples R China

[2] RIKEN, Brain Sci Inst, Adv Technol Dev Grp, Wako, Saitama 3510198, Japan

[3] China Acad Chinese Med Sci, Inst Acupuncture & Moxibust, Beijing 100700, Peoples R China

[4] Iwate Univ, Dept Vet Microbiol, Morioka, Iwate 0208550, Japan

[5] Tokyo Univ Agr & Technol, Inst Symbiot Sci & Technol, Div Anim Sci, Fuchu, Tokyo 1838509, Japan

[6] AIST Neurosci Res Inst, Cognit & Behav Sci Grp, Tsukuba, Ibaraki 3058568, Japan

[7] Japan Sci & Technol Agcy, Core Res Evolut Sci & Technol, Chiyoda Ku, Tokyo 1020075, Japan

[8] Iwate Med Univ, Ctr EM & Bioimaging Res, Morioka, Iwate 0208505, Japan

来源：

JOURNAL OF COMPARATIVE NEUROLOGY | 2013年 / 521卷 / 01期

关键词：

coronavirus; virus replication; transsynaptic transfer; neurons; HEMAGGLUTINATING ENCEPHALOMYELITIS VIRUS; CENTRAL-NERVOUS-SYSTEM; VESICULAR STOMATITIS-VIRUS; ULTRASTRUCTURAL CHARACTERIZATION; EXPERIMENTAL RABIES; VIRAL REPLICATION; TRANSPORT; CORONAVIRUS; INFECTION; GANGLIA;

D O I：

10.1002/cne.23171

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Swine hemagglutinating encephalomyelitis virus (HEV) has been shown to have a capability to propagate via neural circuits to the central nervous system after peripheral inoculation, resulting in acute deadly encephalomyelitis in natural host piglets as well as in experimental younger rodents. This study has systematically examined the assembly and dissemination of HEV 67N in the primary motor cortex of infected rats and provides additional evidence indicating that membranous-coating-mediated endo-/exocytosis can be used by HEV for its transsynaptic transfer. In addition, our results suggested that this transsynaptic pathway could adapted for larger granular materials, such as viruses. These findings should help in understanding the mechanisms underlying coronavirus infections as well as the intercellular exchanges occurring at the synaptic junctions. J. Comp. Neurol. 521:203212, 2013. (C) 2012 Wiley Periodicals, Inc.

引用

页码：203 / 212

页数：10

共 40 条

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