FRAX-Where are we now?

被引：11

作者：

Compston, Juliet ^{[1
]}

机构：

[1] Addenbrookes Hosp, Dept Med, Cambridge CB2 0QQ, England

来源：

MATURITAS | 2015年 / 82卷 / 03期

关键词：

FRAX; Fracture risk prediction; Bone mineral density; RISK-ASSESSMENT; IDENTIFY WOMEN; OSTEOPOROSIS; TOOLS;

D O I：

10.1016/j.maturitas.2015.07.024

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Bone mineral density (BMD) measurements have been widely used in clinical practice for the diagnosis of osteoporosis, monitoring of treatment, and prediction of fracture risk. However, although BMD values show high specificity for prediction of fractures, their sensitivity is quite low. Fracture risk algorithms such as FRAX improve prediction by including clinical risk factors that act independently of BMD. This mini-review discusses the strengths and limitations of FRAX relevant to its use in clinical practice. (C) 2015 Elsevier Ireland Ltd. All rights reserved.

引用

页码：284 / 287

页数：4

共 20 条

[1]

[Anonymous], 1994, World Health Organ Tech Rep Ser, V843, P1

[2]

[Anonymous], OST CLNIC GUID PREV

[3]

[Anonymous], OST ASS RISK FRAG FR

[4]

[Anonymous], UK SUMM M BRUSS BELG

[5] Differing risk profiles for individual fracture sites: Evidence from the global longitudinal study of osteoporosis in women (GLOW) [J].

FitzGerald, Gordon ;

Boonen, Steven ;

Compston, Juliet E. ;

Pfeilschifter, Johannes ;

LaCroix, Andrea Z. ;

Hosmer, David W., Jr. ;

Hooven, Frederick H. ;

Gehlbach, Stephen H. .

JOURNAL OF BONE AND MINERAL RESEARCH, 2012, 27 (09) :1907-1915

[6] Impact of Femoral Neck and Lumbar Spine BMD Discordances on FRAX Probabilities in Women: A Meta-analysis of International Cohorts [J].

Johansson, H. ;

Kanis, J. A. ;

Oden, A. ;

Leslie, W. D. ;

Fujiwara, S. ;

Gluer, C. C. ;

Kroger, H. ;

LaCroix, A. Z. ;

Lau, E. ;

Melton, L. J., III ;

Eisman, J. A. ;

O'Neill, T. W. ;

Goltzman, D. ;

Reid, D. M. ;

McCloskey, E. .

CALCIFIED TISSUE INTERNATIONAL, 2014, 95 (05) :428-435

[7] European guidance for the diagnosis and management of osteoporosis in postmenopausal women [J].

Kanis, J. A. ;

McCloskey, E. V. ;

Johansson, H. ;

Cooper, C. ;

Rizzoli, R. ;

Reginster, J. -Y. .

OSTEOPOROSIS INTERNATIONAL, 2013, 24 (01) :23-57

[8] Guidance for the adjustment of FRAX according to the dose of glucocorticoids [J].

Kanis, J. A. ;

Johansson, H. ;

Oden, A. ;

McCloskey, E. V. .

OSTEOPOROSIS INTERNATIONAL, 2011, 22 (03) :809-816

[9]

Langsetmo L, 2009, J BONE MINER RES, V24, P1515, DOI [10.1359/JBMR.090319, 10.1359/jbmr.090319]

[10] Spine-hip discordance and fracture risk assessment: a physician-friendly FRAX enhancement [J].

Leslie, W. D. ;

Lix, L. M. ;

Johansson, H. ;

Oden, A. ;

McCloskey, E. ;

Kanis, J. A. .

OSTEOPOROSIS INTERNATIONAL, 2011, 22 (03) :839-847

← 1 2 →