Chiral organic contact ion pairs in metal-free catalytic enantioselective oxidative cross-dehydrogenative coupling of tertiary amines to ketones

被引：89
作者：
Zhang, Gen [1 ,2 ]
Ma, Yunxia [1 ,2 ]
Wang, Shoulei [1 ,2 ]
Kong, Weidong [1 ,2 ]
Wang, Rui [1 ,2 ,3 ]
机构：
[1] Lanzhou Univ, Key Lab Preclin Study New Drugs Gansu Prov, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China
[2] Lanzhou Univ, Inst Biochem & Mol Biol, Lanzhou 730000, Peoples R China
[3] Hong Kong Polytech Univ, Dept Appl Biol & Chem Technol, State Key Lab Chirosci, Kowloon, Hong Kong, Peoples R China
来源：
CHEMICAL SCIENCE | 2013年 / 4卷 / 06期
基金：
中国国家自然科学基金;
关键词：
SP(3) C-H; BRONSTED ACID CATALYST; CARBON-HYDROGEN BONDS; MOLECULAR-OXYGEN; NITROGEN ATOM; ASYMMETRIC-SYNTHESIS; TRANSITION-METAL; SODIUM-CYANIDE; TETRAHYDROISOQUINOLINE DERIVATIVES; ISOQUINOLINE ALKALOIDS;
D O I：
10.1039/c3sc50604e
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A novel chiral organic contact ion-pair catalytic system has been developed for the transition-metal-free catalytic enantioselective oxidative cross-dehydrogenative coupling of tertiary amines to ketones for sp(3) C-H functionalization. This new strategy provides an efficient and environmentally friendly way to access diversify optically active C1-alkylated tetrahydroisoquinoline derivatives from simple starting materials under mild conditions.
引用
收藏
页码：2645 / 2651
页数：7
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