Syntheses of oligomannosides in solution and on a soluble polymer support: a comparison

被引：17

作者：

Blattner, R ^{[1
]}

Furneaux, RH ^{[1
]}

Ludewig, M ^{[1
]}

机构：

[1] Ind Res Ltd, Lower Hutt, New Zealand

来源：

CARBOHYDRATE RESEARCH | 2006年 / 341卷 / 03期

关键词：

mannose oligosaccharides; solution synthesis; MPEG-supported synthesis;

D O I：

10.1016/j.carres.2005.11.027

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The alpha-(1 -> 6)-linked and the alpha-(1 -> 2)-linked linear mannotetraose glycosides 3 and 4, respectively, and the branched mannopentaoside 2 [R = CH2(CH2)(2)CH2Cl] were synthesised by conventional methods in Solution, using trichloroacetimidate donors, and the products were obtained in 39%, 42% and 40%, overall yield, respectively. For comparative purposes, the same two linear tetrasaccharides were prepared by use or MPEG as a soluble polymer support, the yields being 34% and 14%, respectively. An attempted MPEG-supported synthesis of the branched pentasaccharide was unsuccessful. The merits and shortcomings of oligosaccharide syntheses on MPEG are discussed. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：299 / 321

页数：23

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