Neurotrophin regulation of neural circuit development and function

被引：1529

作者：

Park, Hyungju ^{[1
]}

Poo, Mu-ming ^{[1
]}

机构：

[1] Univ Calif Berkeley, Helen Wills Neurosci Inst, Dept Mol & Cell Biol, Div Neurobiol, Berkeley, CA 94720 USA

来源：

NATURE REVIEWS NEUROSCIENCE | 2013年 / 14卷 / 01期

基金：

美国国家卫生研究院;

关键词：

LONG-TERM-POTENTIATION; NERVE GROWTH-FACTOR; DEVELOPING NEUROMUSCULAR SYNAPSES; ACTIVITY-DEPENDENT SECRETION; RETINAL GANGLION-CELLS; DEVELOPING RETINOTECTAL SYSTEM; CULTURED HIPPOCAMPAL-NEURONS; INDUCED SYNAPTIC PLASTICITY; DENDRITIC SPINE MORPHOLOGY; RECEPTOR TYROSINE KINASE;

D O I：

10.1038/nrn3379

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Brain-derived neurotrophic factor (BDNF)-a member of a small family of secreted proteins that includes nerve growth factor, neurotrophin 3 and neurotrophin 4-has emerged as a key regulator of neural circuit development and function. The expression, secretion and actions of BDNF are directly controlled by neural activity, and secreted BDNF is capable of mediating many activity-dependent processes in the mammalian brain, including neuronal differentiation and growth, synapse formation and plasticity, and higher cognitive functions. This Review summarizes some of the recent progress in understanding the cellular and molecular mechanisms underlying neurotrophin regulation of neural circuits. The focus of the article is on BDNF, as this is the most widely expressed and studied neurotrophin in the mammalian brain.

引用

页码：7 / 23

页数：17

共 218 条

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