Palladium-Catalyzed Difluoromethylation of Aryl Chlorides and Bromides with TMSCF2H

被引：36

作者：

Ferguson, Devin M. ^{[1
]}

Malapit, Christian A. ^{[1
]}

Bour, James R. ^{[1
]}

Sanford, Melanie S. ^{[1
]}

机构：

[1] Univ Michigan, Dept Chem, 930 North Univ Ave, Ann Arbor, MI 48109 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2019年 / 84卷 / 06期

关键词：

COPPER-MEDIATED DIFLUOROMETHYLATION; FLUORINE; REAGENT; IODIDES; HALIDES; TRIFLUOROMETHYLATION; COUPLINGS; ARENES; ACIDS;

D O I：

10.1021/acs.joc.9b00324

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A palladium-catalyzed cross-coupling of aryl chlorides/bromides with TMSCF2H is described. Two different catalysts, Pd(dba)(2)/BrettPhos and Pd((PBu3)-Bu-t)(2), are demonstrated and provide a variety of difluoromethylated arenes in good yields.

引用

页码：3735 / 3740

页数：6

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