Synthesis of Some Novel Pyrazole-Substituted 9-Anilinoacridine Derivatives and Evaluation for their Antioxidant and Cytotoxic Activities

被引：25

作者：

Kalirajan, R. ^{[1
]}

Muralidharan, V. ^{[1
]}

Jubie, S. ^{[1
]}

Gowramma, B. ^{[1
]}

Gomathy, S. ^{[1
]}

Sankar, S. ^{[1
]}

Elango, K. ^{[1
]}

机构：

[1] JSS Univ, JSS Coll Pharm, Dept Pharmaceut Chem, Ootacamund 643001, Tamil Nadu, India

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 2012年 / 49卷 / 04期

关键词：

N-MUSTARD RESIDUE; ANTITUMOR AGENTS; POTENT; ANILINO; BEARING;

D O I：

10.1002/jhet.848

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

This article focuses on the synthesis of new series of pyrazole-substituted 9-anilinoacridine derivatives 5am and 6al. The compounds were confirmed by physical and analytical data. The synthesized compounds when screened for in vitro antioxidant activity showed promising activity for many compounds. The selected compounds were screened for cytotoxic activity showed promising inhibition of HEp-2 cell line for the compounds 6c, 6e, and 6f.

引用

页码：748 / 754

页数：7

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