A phase Ib, multicenter, open-label study of the antibody-drug conjugate trastuzumab deruxtecan (DS-8201a) combination with nivolumab for advanced HER2-expressing breast or urothelial cancer

被引:0
作者
Hurvitz, S. A. [1 ]
Galsky, M. D. [2 ]
Shahidi, J. [3 ]
Zhang, G. [4 ]
Raza, S. [3 ]
Necchi, A. [5 ]
机构
[1] UCLA Med Ctr, Dept Med, Los Angeles, CA USA
[2] Icahn Sch Med Mt Sinai, Dept Med, New York, NY 10029 USA
[3] Daiichi Sankyo Inc, Clin Dev, Basking Ridge, NJ USA
[4] Daiichi Sankyo Inc, Biostat & Data Management, Basking Ridge, NJ USA
[5] Fdn IRCCS Ist Nazl Tumori, Med Oncol, Milan, Italy
关键词
D O I
暂无
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
370TiP
引用
收藏
页数:1
相关论文
共 50 条
[41]   [Fam-] trastuzumab deruxtecan (T-DXd; DS-8201a) in subjects with HER2-positive metastatic breast cancer previously treated with T-DM1: A phase 2, multicenter, open-label study (DESTINY-Breast01) [J].
Krop, Ian E. ;
Saura, Cristina ;
Yamashita, Toshinari ;
Park, Yeon Hee ;
Kim, Sung-Bae ;
Tamura, Kenji ;
Andre, Fabrice ;
Iwata, Hiroji ;
Ito, Yoshinori ;
Tsurutani, Junji ;
Sohn, Joohyuk ;
Denduluri, Neelima ;
Perrin, Christophe ;
Aogi, Kenjiro ;
Tokunaga, Eriko ;
Im, Seock-Ah ;
Lee, Keun Seok ;
Hurvitz, Sara ;
Cortes, Javier ;
Lee, Caleb ;
Chen, Shuquan ;
Zhang, Lin ;
Shahidi, Javad ;
Yver, Antoine ;
Modi, Shanu .
CANCER RESEARCH, 2020, 80 (04)
[42]   DS-8201a, a HER2-targeting antibody-drug conjugate, to elicit immune responses and benefits in combination with an anti-PD-1 antibody. [J].
Iwata, Tomomi Nakayama ;
Ishii, Chiaki ;
Ogitani, Yusuke ;
Wada, Teiji ;
Agatsuma, Toshinori .
JOURNAL OF CLINICAL ONCOLOGY, 2017, 35
[43]   Open-label, Multicenter, Phase II Study of RC48-ADC, a HER2-Targeting Antibody-Drug Conjugate, in Patients with Locally Advanced or Metastatic Urothelial Carcinoma [J].
Sheng, Xinan ;
Yan, Xieqiao ;
Wang, Lin ;
Shi, Yanxia ;
Yao, Xin ;
Luo, Hong ;
Shi, Benkang ;
Liu, Jiyan ;
He, Zhisong ;
Yu, Guohua ;
Ying, Jianming ;
Han, Weiqing ;
Hu, Changlu ;
Ling, Yun ;
Chi, Zhihong ;
Cui, Chuanliang ;
Si, Lu ;
Fang, Jianmin ;
Zhou, Aiping ;
Guo, Jun .
CLINICAL CANCER RESEARCH, 2021, 27 (01) :43-51
[44]   A phase 1 study of DS-8201a in combination with olaparib in HER2-expressing malignancies (CTEP #10355): Results of module 1 dose escalation [J].
Lee, Elizabeth K. ;
Hendrickson, Andrea E. Wahner ;
Colon-Otero, Gerardo ;
Pickett, Cheryl A. ;
Xiong, Niya ;
Cheng, Su-Chun ;
Polak, Madeline ;
Sawyer, Hannah ;
Hayes, Martin ;
Matulonis, Ursula A. ;
Shapiro, Geoffrey I. ;
Konstantinopoulos, Panagiotis A. .
MOLECULAR CANCER THERAPEUTICS, 2023, 22 (12)
[45]   POPULATION PHARMACOKINETIC ANALYSIS OF DS-8201A, A HER2-TARGETING ANTIBODY-DRUG CONJUGATE, IN PATIENTS WITH HER2-POSITIVE BREAST CANCER OR OTHER SOLID TUMORS. [J].
Yin, O. ;
Xiong, Y. ;
Endo, S. ;
Yoshihara, K. ;
AbuTarif, M. ;
Wada, R. ;
LaCreta, F. .
CLINICAL PHARMACOLOGY & THERAPEUTICS, 2019, 105 :S48-S48
[46]   A phase II study of [fam-] trastuzumab deruxtecan (DS-8201a) in HER2-overexpressing or -mutated advanced non-small cell lung cancer [J].
Planchard, D. ;
Li, B. T. ;
Murakami, H. ;
Shiga, R. ;
Lee, C. C. ;
Wang, K. ;
Janne, P. A. .
ANNALS OF ONCOLOGY, 2019, 30
[47]   EXPOSURE-RESPONSE ANALYSES TO SUPPORT DOSE JUSTIFICATION OF DS-8201A, A HER2-TARGETING ANTIBODY-DRUG CONJUGATE, IN HER2-POSITIVE BREAST CANCER PATIENTS. [J].
Yin, O. ;
Wada, R. ;
Kastrissios, H. ;
AbuTarif, M. ;
Garimella, T. ;
Lee, C. ;
Zhang, L. ;
Shahidi, J. ;
LaCreta, F. .
CLINICAL PHARMACOLOGY & THERAPEUTICS, 2019, 105 :S41-S41
[48]   EXPOSURE-RESPONSE ANALYSES TO SUPPORT DOSE JUSTIFICATION OF DS-8201A, A HER2-TARGETING ANTIBODY-DRUG CONJUGATE, IN HER2-POSITIVE BREAST CANCER PATIENTS. [J].
Yin, O. ;
Wada, R. ;
Kastrissios, H. ;
AbuTarif, M. ;
Garimella, T. ;
Lee, C. ;
Zhang, L. ;
Shahidi, J. ;
LaCreta, F. .
CLINICAL PHARMACOLOGY & THERAPEUTICS, 2019, 105 :S48-S48
[49]   Safety, pharmacokinetics, and antitumour activity of trastuzumab deruxtecan (DS-8201), a HER2-targeting antibody-drug conjugate, in patients with advanced breast and gastric or gastro-oesophageal tumours: a phase 1 dose-escalation study [J].
Doi, Toshihiko ;
Shitara, Kohei ;
Naito, Yoichi ;
Shimomura, Akihiko ;
Fujiwara, Yasuhiro ;
Yonemori, Kan ;
Shimizu, Chikako ;
Shimoi, Tatsunori ;
Kuboki, Yasutoshi ;
Matsubara, Nobuaki ;
Kitano, Atsuko ;
Jikoh, Takahiro ;
Lee, Caleb ;
Fujisaki, Yoshihiko ;
Ogitani, Yusuke ;
Yver, Antoine ;
Tamura, Kenji .
LANCET ONCOLOGY, 2017, 18 (11) :1512-1522
[50]   A phase II, multicenter, open-label study evaluating trastuzumab deruxtecan (T-DXd) for the treatment of select HER2-expressing solid tumors (DESTINY-PanTumor02) [J].
Meric-Bernstam, F. ;
Anoka, C. ;
Dobrowolska, A. ;
Chaudhry, A. ;
Rowbottom, J. ;
Gustavson, M. ;
Puvvada, S. .
ANNALS OF ONCOLOGY, 2021, 32 :S1253-S1254