Unresolved issues and controversies in purinergic signalling

被引:48
作者
Burnstock, Geoffrey [1 ]
机构
[1] UCL Royal Free & Univ Coll Med Sch, Autonom Neurosci Ctr, London NW3 2PF, England
来源
JOURNAL OF PHYSIOLOGY-LONDON | 2008年 / 586卷 / 14期
关键词
D O I
10.1113/jphysiol.2008.155903
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Some areas of current interest in the rapidly expanding purinergic signalling field that are controversial or are unresolved are highlighted in this review. These include the mechanisms underlying: ATP transport across cell and vesicle membranes; the interaction of multiple receptors for purines and pyrimidines on single cells; the blocking effect of antagonists to P2X(4) and P2X(7) receptors expressed by microglial cells in neuropathic and inflammatory pain; and the complex actions mediated by P2X(7) receptors. Some desirable areas for further research are also discussed including: comparative studies of the evolution of purinergic signalling; studies of purinergic signalling in development and regeneration, including the involvement of stem cells; behavioural studies; and therapeutic strategies.
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页码:3307 / 3312
页数:6
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