Unresolved issues and controversies in purinergic signalling
被引:48
作者:
Burnstock, Geoffrey
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机构:
UCL Royal Free & Univ Coll Med Sch, Autonom Neurosci Ctr, London NW3 2PF, EnglandUCL Royal Free & Univ Coll Med Sch, Autonom Neurosci Ctr, London NW3 2PF, England
Burnstock, Geoffrey
[1
]
机构:
[1] UCL Royal Free & Univ Coll Med Sch, Autonom Neurosci Ctr, London NW3 2PF, England
来源:
JOURNAL OF PHYSIOLOGY-LONDON
|
2008年
/
586卷
/
14期
关键词:
D O I:
10.1113/jphysiol.2008.155903
中图分类号:
Q189 [神经科学];
学科分类号:
071006 ;
摘要:
Some areas of current interest in the rapidly expanding purinergic signalling field that are controversial or are unresolved are highlighted in this review. These include the mechanisms underlying: ATP transport across cell and vesicle membranes; the interaction of multiple receptors for purines and pyrimidines on single cells; the blocking effect of antagonists to P2X(4) and P2X(7) receptors expressed by microglial cells in neuropathic and inflammatory pain; and the complex actions mediated by P2X(7) receptors. Some desirable areas for further research are also discussed including: comparative studies of the evolution of purinergic signalling; studies of purinergic signalling in development and regeneration, including the involvement of stem cells; behavioural studies; and therapeutic strategies.
机构:
UCL Royal Free & Univ Coll Med Sch, Auton Neurosci Inst, Dept Anat & Dev Biol, London NW3 2PF, EnglandUCL Royal Free & Univ Coll Med Sch, Auton Neurosci Inst, Dept Anat & Dev Biol, London NW3 2PF, England
Bodin, P
Burnstock, G
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机构:
UCL Royal Free & Univ Coll Med Sch, Auton Neurosci Inst, Dept Anat & Dev Biol, London NW3 2PF, EnglandUCL Royal Free & Univ Coll Med Sch, Auton Neurosci Inst, Dept Anat & Dev Biol, London NW3 2PF, England
机构:
Kings Coll London, Guys Kings & St Thomas Sch Biomed Sci, London SE1 7EH, EnglandKings Coll London, Guys Kings & St Thomas Sch Biomed Sci, London SE1 7EH, England
Bradbury, EJ
Burnstock, G
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机构:Kings Coll London, Guys Kings & St Thomas Sch Biomed Sci, London SE1 7EH, England
Burnstock, G
McMahon, SB
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机构:Kings Coll London, Guys Kings & St Thomas Sch Biomed Sci, London SE1 7EH, England
机构:
UCL Royal Free & Univ Coll, Med Sch, Autonom Neurosci Ctr, London NWS 2PF, EnglandUCL Royal Free & Univ Coll, Med Sch, Autonom Neurosci Ctr, London NWS 2PF, England
机构:
UCL Royal Free & Univ Coll Med Sch, Auton Neurosci Inst, Dept Anat & Dev Biol, London NW3 2PF, EnglandUCL Royal Free & Univ Coll Med Sch, Auton Neurosci Inst, Dept Anat & Dev Biol, London NW3 2PF, England
Bodin, P
Burnstock, G
论文数: 0引用数: 0
h-index: 0
机构:
UCL Royal Free & Univ Coll Med Sch, Auton Neurosci Inst, Dept Anat & Dev Biol, London NW3 2PF, EnglandUCL Royal Free & Univ Coll Med Sch, Auton Neurosci Inst, Dept Anat & Dev Biol, London NW3 2PF, England
机构:
Kings Coll London, Guys Kings & St Thomas Sch Biomed Sci, London SE1 7EH, EnglandKings Coll London, Guys Kings & St Thomas Sch Biomed Sci, London SE1 7EH, England
Bradbury, EJ
Burnstock, G
论文数: 0引用数: 0
h-index: 0
机构:Kings Coll London, Guys Kings & St Thomas Sch Biomed Sci, London SE1 7EH, England
Burnstock, G
McMahon, SB
论文数: 0引用数: 0
h-index: 0
机构:Kings Coll London, Guys Kings & St Thomas Sch Biomed Sci, London SE1 7EH, England
机构:
UCL Royal Free & Univ Coll, Med Sch, Autonom Neurosci Ctr, London NWS 2PF, EnglandUCL Royal Free & Univ Coll, Med Sch, Autonom Neurosci Ctr, London NWS 2PF, England