Development of an industrial multi-injection microreactor for fast and exothermic reactions - Part II

被引：63

作者：

Roberge, Dominique M. ^{[1
]}

Bieler, Nikolaus ^{[2
]}

Mathier, Meinrad ^{[2
]}

Eyholzer, Markus ^{[2
]}

Zimmermann, Bertin ^{[2
]}

Barthe, Philippe ^{[3
]}

Guermeur, Celine ^{[3
]}

Lobet, Olivier ^{[3
]}

Moreno, Maxime ^{[3
]}

Woehl, Pierre ^{[3
]}

机构：

[1] Univ Ottawa, Ottawa, ON K1N 6N5, Canada

[2] Lonaz Ltd, Visp, Switzerland

[3] Corning SAS, Corning European Technol Ctr, Avon, France

来源：

CHEMICAL ENGINEERING & TECHNOLOGY | 2008年 / 31卷 / 08期

关键词：

exothermic reactions; multi-injection microreactors;

D O I：

10.1002/ceat.200800131

中图分类号：

TQ [化学工业];

学科分类号：

0817 ;

摘要：

A Grignard reaction performed in a microreactor is presented. The reaction is of type A (highly exothermic and very rapid) and has a low yield which is attributed to a hot spot formed in the mixing zone of the reactor. The reaction yield could be significantly increased by applying the multi-injection principle, leading to better thermal control in the microreactor. Nevertheless, the microreactor plays a major role in reducing the magnitude of the hot spot. Knowing this, it was possible to design and construct an industrial microreactor with significant advantages such as modularity, high flow rate operation, and low investment expenditure (pumps and flow controller minimization).

引用

页码：1155 / 1161

页数：7

共 26 条

[1]

Barth S, 2008, ECONTENT, V31, P32

[2] A flow process for the multi-step synthesis of the alkaloid natural product oxomaritidine: a new paradigm for molecular assembly [J].