Clinical Manifestations and Bacterial Genomic Analysis of Group A Streptococcus Strains That Cause Pediatric Toxic Shock Syndrome

被引：7

作者：

Deniskin, Roman ^{[1
]}

Shah, Brittany ^{[4
]}

Munoz, Flor M. ^{[1
,2
,3
]}

Flores, Anthony R. ^{[4
]}

机构：

[1] Baylor Coll Med, Dept Pediat, Houston, TX 77030 USA

[2] Baylor Coll Med, Sect Infect Dis, Houston, TX 77030 USA

[3] Texas Childrens Hosp, Houston, TX 77030 USA

[4] Univ Texas Hlth Sci Ctr Houston, McGovern Med Sch, Ctr Antimicrobial Resistance & Microbial Genom, Div Infect Dis,Dept Pediat, Houston, TX 77030 USA

来源：

JOURNAL OF THE PEDIATRIC INFECTIOUS DISEASES SOCIETY | 2019年 / 8卷 / 03期

基金：

美国国家卫生研究院;

关键词：

emm type; group A Streptococcus; invasive; shock; STSS; MOLECULAR-BASIS; INFECTIONS;

D O I：

10.1093/jpids/piy069

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

We report here 18 cases of pediatric group A streptococcal toxic shock syndrome, associated clinical findings, and bacterial molecular genetic characteristics discovered through whole-genome sequencing. This comparative whole-genome sequencing revealed unique gene content (speK) and polymorphisms (dpiB) in emm87 group A Streptococcus, the relative contributions of which, in combination with the host response, in the development of streptococcal toxic shock syndrome remain to be elucidated.

引用

页码：265 / 268

页数：4

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