Recent Developments in Asymmetric Alkynylation of Imines

被引：92
作者：
Blay, G. [1 ]
Monleon, A. [1 ]
Pedro, J. R. [1 ]
机构：
[1] Univ Valencia, Dept Quim Organ, Fac Quim, E-46100 Valencia, Spain
来源：
CURRENT ORGANIC CHEMISTRY | 2009年 / 13卷 / 15期
关键词：
HIGHLY ENANTIOSELECTIVE SYNTHESIS; COMPLEX-CATALYZED SYNTHESIS; POT 3-COMPONENT SYNTHESIS; AMINO-ACID DERIVATIVES; TERMINAL ALKYNES; DIRECT-ADDITION; ALKYNYLZINC REAGENTS; DIASTEREOSELECTIVE ADDITION; STEREOSELECTIVE-SYNTHESIS; RADICAL CYCLIZATION;
D O I：
10.2174/138527209789177734
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
This review deals with the asymmetric alkynylation of imines (and iminium ions) to give chiral nonracemic propargylamines. Diastereoselective procedures involved the addition of metal alkynylides to chiral nonracemic imines derived from chiral amines or chiral carbonyl compounds. Enantioselective non-catalytic procedures have been achieved with the use of stoichiometric additives or alkynylboron reagents. Finally, catalytic addition of terminal alkynes or zinc acetylides has been carried out in the presence of chiral metal complexes, especially copper complexes as catalysts.
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页码：1498 / 1539
页数：42
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