Microwave-assisted synthesis of indole-derivatives via cycloisomerization of 2-alkynylanilines in water without added catalysts, acids, or bases

被引：24

作者：

Carpita, Adriano ^{[2
]}

Ribecai, Arianna ^{[1
]}

机构：

[1] GlaxoSmithKline SpA, Chem Dev Dept, I-37135 Verona, Italy

[2] Univ Pisa, Dipartimento Chim & Chim Ind, I-56126 Pisa, Italy

来源：

TETRAHEDRON LETTERS | 2009年 / 50卷 / 49期

关键词：

Indoles; Water; Cycloisomerization; Microwaves; 2-Alkynylanilines; Green chemistry; ONE-POT SYNTHESIS; NEAR-CRITICAL WATER; 2-ETHYNYLANILINE DERIVATIVES; INTRAMOLECULAR HYDROAMINATION; 2-SUBSTITUTED INDOLES; CYCLIZATION REACTIONS; CONVENIENT SYNTHESIS; TERMINAL ALKYNES; ARYL IODIDES; PALLADIUM;

D O I：

10.1016/j.tetlet.2009.09.135

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An unprecedented green methodology is described for the preparation of differently substituted indoles via microwave-assisted cycloisomerization of 2-alkynylaniline derivatives in water. Moderate to good yields in the cyclization can be achieved for a variety of 2-aminoaryl alkynes. Reactions are run without any added metal catalyst, acid, or base, and do not take place by applying conventional heating. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：6877 / 6881

页数：5

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