Nutrient-Induced Cellular Mechanisms of Gut Hormone Secretion

被引：67
作者：
Lu, Van B. [1 ]
Gribble, Fiona M. [1 ]
Reimann, Frank [1 ]
机构：
[1] Univ Cambridge, Wellcome Trust MRC Inst Sci, Metab Res Lab, Addenbrookes Hosp, Cambridge CB2 0QQ, England
来源：
NUTRIENTS | 2021年 / 13卷 / 03期
基金：
英国惠康基金; 英国医学研究理事会;
关键词：
enteroendocrine cells; chemosensory; GIP; GLP-1; nutrients; hormones; GLUCAGON-LIKE PEPTIDE-1; GASTRIC-INHIBITORY POLYPEPTIDE; FATTY-ACID RECEPTOR; PROTEIN-COUPLED RECEPTOR; CALCIUM-SENSING RECEPTOR; CAPSAICIN ATTENUATES SUPPRESSION; INTESTINAL GLUCOSE-ABSORPTION; CENTRAL-NERVOUS-SYSTEM; SWEET TASTE RECEPTOR; REDUCES FOOD-INTAKE;
D O I：
10.3390/nu13030883
中图分类号：
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号：
100403 ;
摘要：
The gastrointestinal tract can assess the nutrient composition of ingested food. The nutrient-sensing mechanisms in specialised epithelial cells lining the gastrointestinal tract, the enteroendocrine cells, trigger the release of gut hormones that provide important local and central feedback signals to regulate nutrient utilisation and feeding behaviour. The evidence for nutrient-stimulated secretion of two of the most studied gut hormones, glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), along with the known cellular mechanisms in enteroendocrine cells recruited by nutrients, will be the focus of this review. The mechanisms involved range from electrogenic transporters, ion channel modulation and nutrient-activated G-protein coupled receptors that converge on the release machinery controlling hormone secretion. Elucidation of these mechanisms will provide much needed insight into postprandial physiology and identify tractable dietary approaches to potentially manage nutrition and satiety by altering the secreted gut hormone profile.
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页码：1 / 36
页数：36
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