Epithelial Mesenchymal Transition in Lung Cancer Cells: A Quantitative Analysis

被引：0

作者：

Sarkar, Atasi ^{[1
]}

Barui, A. ^{[2
]}

Sengupta, S. ^{[3
]}

Chatterjee, J. ^{[1
]}

Ghorai, S. ^{[4
]}

Mukherjee, Anirban ^{[5
]}

机构：

[1] Indian Inst Technol, Sch Med Sci & Technol, Kharagpur 721302, WB, India

[2] Indian Inst Engn Sci & Technol, Ctr Healthcare Sci & Technol, Sibpur 711103, WB, India

[3] Univ Calcutta, Dept Biochem, Kolkata 700019, WB, India

[4] Heritage Inst Technol, Kolkata 700107, WB, India

[5] Indian Inst Technol, Dept Elect Engn, Kharagpur 721302, WB, India

来源：

2015 37TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY (EMBC) | 2015年

关键词：

D O I：

暂无

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Cellular auto-fluorescence along with morphological and cytoskeletal features were assessed in lung cancer cells undergoing induced epithelial mesenchymal transition (EMT). During EMT progression, significant increase was observed in cellular aspect ratio (AR), filamentous (F)-actin and green auto-fluorescence intensities while blue intensity decreased. These features were provided to a kernel classification framework. The classification accuracy were impressive, thus these features along with the classification technique can be considered as suitable tools for automated grading of lung cancer cells undergoing EMT progression.

引用

页码：5372 / 5375

页数：4

共 8 条

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