Disposition kinetics of tylosin administered intravenously and intramuscularly to pigs

被引：25

作者：

Prats, C ^{[1
]}

El Korchi, G

Francesch, R

Arboix, M

Pérez, B

机构：

[1] Univ Autonoma Barcelona, Dept Farmacol Terapeut & Toxicol, Fac Vet, Bellaterra 08193, Spain

[2] LABIANA Life Sci SA, Terrassa, Spain

来源：

RESEARCH IN VETERINARY SCIENCE | 2002年 / 73卷 / 02期

关键词：

D O I：

10.1016/S0034-5288(02)00036-X

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

The distribution of tylosin was studied using a crossover design, in six pigs following i.v. and i.m. administration of 10 mg kg(-1) b.w. Plasma samples were analysed by HPLC and UV absorbance detection. After i.v. administration, t(1/2beta) was 271.3 min, V-d 14.6 L kg(-1), V-SS 9.7 L kg(-1) and CL 26.8 mL min(-1) kg(-1). After i.m. administration, a C-max of 1 mug mL(-1) was reached at 90 min. Mean absorption time was 1988.7 min and bioavailability was 95%. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：141 / 144

页数：4

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