Shaping the future: recent advances of 3D printing in drug delivery and healthcare

被引：207
作者：
Trenfield, Sarah J. [1 ]
Awad, Atheer [1 ]
Madla, Christine M. [1 ]
Hatton, Grace B. [1 ]
Firth, Jack [2 ]
Goyanes, Alvaro [3 ,4 ]
Gaisford, Simon [1 ,3 ]
Basit, Abdul W. [1 ,3 ]
机构：
[1] UCL, UCL Sch Pharm, 29-39 Brunswick Sq, London WC1N 1AX, England
[2] UCL, Dept Biochem Engn, London, England
[3] FabRx Ltd, Ashford TN24 0RW, Kent, England
[4] Univ Santiago de Compostela, R D Pharma Grp GI 1645, Dept Farmacol Farm & Tecnol Farmaceut, Santiago De Compostela, Spain
来源：
EXPERT OPINION ON DRUG DELIVERY | 2019年 / 16卷 / 10期
基金：
英国工程与自然科学研究理事会;
关键词：
Three-dimensional printing; oral drug delivery systems; digital healthcare; additive manufacturing; 3 & xfeff; D-printed drug products; personalized pharmaceuticals; RAMAN-SPECTROSCOPY; QUALITY-CONTROL; DOSAGE FORMS; RELEASE; INKJET; FABRICATION; SCAFFOLDS; IMMEDIATE; DEVICES; TABLETS;
D O I：
10.1080/17425247.2019.1660318
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Introduction: Three-dimensional (3D) printing is a relatively new, rapid manufacturing technology that has found promising applications in the drug delivery and medical sectors. Arguably, never before has the healthcare industry experienced such a transformative technology. This review aims to discuss the state of the art of 3D printing technology in healthcare and drug delivery. Areas covered: The current and future applications of printing technologies within drug delivery and medicine have been discussed. The latest innovations in 3D printing of customized medical devices, drug-eluting implants, and printlets (3D-printed tablets) with a tailored dose, shape, size, and release characteristics have been covered. The review also covers the state of the art of 3D printing in healthcare (covering topics such as dentistry, surgical and bioprinting of patient-specific organs), as well as the potential of recent innovations, such as 4D printing, to shape the future of drug delivery and to improve treatment pathways for patients. Expert opinion: A future perspective is provided on the potential for 3D printing in healthcare, covering strategies to overcome the major barriers to integration that are faced today.
引用
收藏
页码：1081 / 1094
页数：14
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