Protein and polysaccharide conjugates as emerging scaffolds for drug delivery systems

被引：10

作者：

Xu, Amy Y. ^{[1
,2
]}

Melton, Laurence D. ^{[1
,2
]}

Williams, Martin A. K. ^{[2
,3
,4
]}

McGillivray, Duncan J. ^{[1
,3
]}

机构：

[1] Univ Auckland, Sch Chem Sci, Private Bag 92019, Auckland 1142, New Zealand

[2] Riddet Inst Ctr Res Excellence, Private Bag 11222, Palmerston North 4442, New Zealand

[3] MacDiarmid Inst Adv Mat & Nanotechnol, POB 600, Wellington 6140, New Zealand

[4] Massey Univ, Inst Fundamental Sci, Private Bag 11222, Palmerston North 4442, New Zealand

来源：

INTERNATIONAL JOURNAL OF NANOTECHNOLOGY | 2017年 / 14卷 / 1-6期

关键词：

protein; polysaccharide; conjugates; nanomaterial; CONTROLLED-RELEASE; CORN PROTEIN; ZEIN; NANOPARTICLES; ENCAPSULATION; MICROSPHERES; HYDROGEL;

D O I：

10.1504/IJNT.2017.082468

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

Protein and polysaccharide conjugates are ideal for developing coatings for medical scaffolds and drug delivery systems owing to their high biocompatibility and biodegradability. In this study, we are conjugating a hydrophobic protein zein with a hydrophilic polysaccharide, pectin. A specific covalent linkage is introduced between the reducing end of pectin and the amine groups of zein that are surface accessible. After successful coupling of pectin to zein, the conjugate is water-soluble. A film was prepared with the zein-pectin conjugates on a hydrophilic silica surface. SEM shows that the film is mainly composed of zein nanoparticles coated with pectin, and these nanoparticles arrange themselves into individual arrays that are separated by several wide channels. Films with such nanostructures can be exploited for developing bioactive coatings.

引用

页码：470 / 480

页数：11

共 21 条

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