Role of the Monocyte-Macrophage System in Normal Pregnancy and Preeclampsia

被引：64
作者：
Vishnyakova, Polina [1 ]
Elchaninov, Andrey [1 ,2 ]
Fatkhudinov, Timur [2 ,3 ]
Sukhikh, Gennady [1 ]
机构：
[1] Minist Healthcare Russian Federat, Natl Med Res Ctr Obstet Gynecol & Perinatol, 4 Oparina St, Moscow 117997, Russia
[2] Peoples Friendship Univ Russia, 6 Miklukho Maklaya St, Moscow 117198, Russia
[3] Sci Res Inst Human Morphol, 3 Tsurupa St, Moscow 117418, Russia
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2019年 / 20卷 / 15期
关键词：
preeclampsia; monocyte; macrophage; placenta; decidua; inflammation; SYNCYTIOTROPHOBLAST EXTRACELLULAR VESICLES; HOFBAUER CELLS; T-CELLS; IMMUNE TOLERANCE; TISSUE-REPAIR; SEX-HORMONES; ESTROGEN; EXPRESSION; ACTIVATION; BLOOD;
D O I：
10.3390/ijms20153695
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The proper functioning of the monocyte-macrophage system, an important unit of innate immunity, ensures the normal course of pregnancy. In this review, we present the current data on the origin of the monocyte-macrophage system and its functioning in the female reproductive system during the ovarian cycle, and over the course of both normal and complicated pregnancy. Preeclampsia is a crucial gestation disorder characterized by pronounced inflammation in the maternal body that affects the work of the monocyte-macrophage system. The effects of inflammation at preeclampsia manifest in changes in monocyte counts and their subset composition, and changes in placental macrophage counts and their polarization. Here we summarize the recent data on this issue for both the maternal organism and the fetus. The influence of estrogen on macrophages and their altered levels in preeclampsia are also discussed.
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页数：17
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共 122 条
  • [61] Androgens in pregnancy: roles in parturition
    Makieva, Sofia
    Saunders, Philippa T. K.
    Norman, Jane E.
    [J]. HUMAN REPRODUCTION UPDATE, 2014, 20 (04) : 542 - 559
  • [62] Current Concept and Update of the Macrophage Plasticity Concept: Intracellular Mechanisms of Reprogramming and M3 Macrophage "Switch" Phenotype
    Malyshev, Igor
    Malyshev, Yuri
    [J]. BIOMED RESEARCH INTERNATIONAL, 2015, 2015
  • [63] Margaryan S, 2017, HORM MOL BIOL CLIN I, V30, DOI 10.1515/hmbci-2016-0046
  • [64] Martinez Fernando O, 2014, F1000Prime Rep, V6, P13, DOI 10.12703/P6-13
  • [65] Pregnancy and Preeclampsia Affect Monocyte Subsets in Humans and Rats
    Melgert, Barbro N.
    Spaans, Floor
    Borghuis, Theo
    Klok, Pieter A.
    Groen, Bart
    Bolt, Annemarie
    de Vos, Paul
    van Pampus, Maria G.
    Wong, Tsz Y.
    van Goor, Harry
    Bakker, Winston W.
    Faas, Marijke M.
    [J]. PLOS ONE, 2012, 7 (09):
  • [66] Murine Monocytes: Origins, Subsets, Fates, and Functions
    Mildner, Alexander
    Marinkovic, Goran
    Jung, Steffen
    [J]. MICROBIOLOGY SPECTRUM, 2016, 4 (05):
  • [67] Anatomy of a discovery: M1 and M2 macrophages
    Mills, Charles Dudley
    [J]. FRONTIERS IN IMMUNOLOGY, 2015, 6
  • [68] Number of decidual natural killer cells & macrophages in pre-eclampsia
    Milosevic-Stevanovic, Jelena
    Krstic, Miljan
    Radovic-Janosevic, Dragana
    Popovic, Jasmina
    Tasic, Marija
    Stojnev, Slavica
    [J]. INDIAN JOURNAL OF MEDICAL RESEARCH, 2016, 144 : 823 - 830
  • [69] Interaction of the estrogen receptors with the Fas ligand promoter in human monocytes
    Mor, G
    Sapi, E
    Abrahams, VM
    Rutherford, T
    Song, J
    Hao, XY
    Muzaffar, S
    Kohen, F
    [J]. JOURNAL OF IMMUNOLOGY, 2003, 170 (01) : 114 - 122
  • [70] Inflammation and pregnancy: the role of the immune system at the implantation site
    Mor, Gil
    Cardenas, Ingrid
    Abrahams, Vikki
    Guller, Seth
    [J]. REPRODUCTIVE SCIENCE, 2011, 1221 : 80 - 87
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