Role of the Monocyte-Macrophage System in Normal Pregnancy and Preeclampsia

被引：64
作者：
Vishnyakova, Polina [1 ]
Elchaninov, Andrey [1 ,2 ]
Fatkhudinov, Timur [2 ,3 ]
Sukhikh, Gennady [1 ]
机构：
[1] Minist Healthcare Russian Federat, Natl Med Res Ctr Obstet Gynecol & Perinatol, 4 Oparina St, Moscow 117997, Russia
[2] Peoples Friendship Univ Russia, 6 Miklukho Maklaya St, Moscow 117198, Russia
[3] Sci Res Inst Human Morphol, 3 Tsurupa St, Moscow 117418, Russia
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2019年 / 20卷 / 15期
关键词：
preeclampsia; monocyte; macrophage; placenta; decidua; inflammation; SYNCYTIOTROPHOBLAST EXTRACELLULAR VESICLES; HOFBAUER CELLS; T-CELLS; IMMUNE TOLERANCE; TISSUE-REPAIR; SEX-HORMONES; ESTROGEN; EXPRESSION; ACTIVATION; BLOOD;
D O I：
10.3390/ijms20153695
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The proper functioning of the monocyte-macrophage system, an important unit of innate immunity, ensures the normal course of pregnancy. In this review, we present the current data on the origin of the monocyte-macrophage system and its functioning in the female reproductive system during the ovarian cycle, and over the course of both normal and complicated pregnancy. Preeclampsia is a crucial gestation disorder characterized by pronounced inflammation in the maternal body that affects the work of the monocyte-macrophage system. The effects of inflammation at preeclampsia manifest in changes in monocyte counts and their subset composition, and changes in placental macrophage counts and their polarization. Here we summarize the recent data on this issue for both the maternal organism and the fetus. The influence of estrogen on macrophages and their altered levels in preeclampsia are also discussed.
引用
收藏
页数：17
相关论文
共 122 条
  • [1] Human Placental Mesenchymal Stem Cells (pMSCs) Play a Role as Immune Suppressive Cells by Shifting Macrophage Differentiation from Inflammatory M1 to Anti-inflammatory M2 Macrophages
    Abumaree, M. H.
    Al Jumah, M. A.
    Kalionis, B.
    Jawdat, D.
    Al Khaldi, A.
    Abomaray, F. M.
    Fatani, A. S.
    Chamley, L. W.
    Knawy, B. A.
    [J]. STEM CELL REVIEWS AND REPORTS, 2013, 9 (05) : 620 - 641
  • [2] Decidua Basalis Mesenchymal Stem Cells Favor Inflammatory M1 Macrophage Differentiation In Vitro
    Abumaree, Mohamed H.
    Al Harthy, Seham
    Al Subayyil, Abdullah M.
    Alshabibi, Manal A.
    Abomaray, Fawaz M.
    Khatlani, Tanvier
    Kalionis, Bill
    El-Muzaini, Mohammed F.
    Al Jumah, Mohammed A.
    Jawdat, Dunia
    Alawad, Abdullah O.
    AlAskar, Ahmed S.
    [J]. CELLS, 2019, 8 (02)
  • [3] Levels of Oxidized LDL, Estrogens, and Progesterone in Placenta Tissues and Serum Paraoxonase Activity in Preeclampsia
    Acikgoz, Serefden
    Bayar, Ulku Ozmen
    Can, Murat
    Guven, Berrak
    Mungan, Gorkem
    Dogan, Suat
    Sumbuloglu, Vildan
    [J]. MEDIATORS OF INFLAMMATION, 2013, 2013
  • [4] Association of pro- and anti-inflammatory cytokines in preeclampsia
    Aggarwal, Ruby
    Jain, Arun Kumar
    Mittal, Pratima
    Kohli, Mangala
    Jawanjal, Poonam
    Rath, Gayatri
    [J]. JOURNAL OF CLINICAL LABORATORY ANALYSIS, 2019, 33 (04)
  • [5] Localization and Counting of CD68-Labelled Macrophages in Placentas of Normal and Preeclamptic Women
    Al-Khafaji, Lina Ali
    Al-Yawer, Malak A.
    [J]. 6TH INTERNATIONAL CONFERENCE AND WORKSHOPS ON BASIC AND APPLIES SCIENCES, 2017, 1888
  • [6] Monocyte Subpopulations from Pre-Eclamptic Patients Are Abnormally Skewed and Exhibit Exaggerated Responses to Toll-Like Receptor Ligands
    Al-ofi, Ebtisam
    Coffelt, Seth B.
    Anumba, Dilly O.
    [J]. PLOS ONE, 2012, 7 (07):
  • [7] Characterization of fetal monocytes in preeclampsia and fetal growth restriction
    Alahakoon, Thushari, I
    Medbury, Heather
    Williams, Helen
    Fewings, Nicole
    Wang, Xin M.
    Lee, Vincent W.
    [J]. JOURNAL OF PERINATAL MEDICINE, 2019, 47 (04) : 434 - 438
  • [8] Distribution of monocyte subsets and polarization in preeclampsia and intrauterine fetal growth restriction
    Alahakoon, Thushari I.
    Medbury, Heather
    Williams, Helen
    Fewings, Nicole
    Wang, Xin M.
    Lee, Vincent W.
    [J]. JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH, 2018, 44 (12) : 2135 - 2148
  • [9] [Anonymous], WHO REC PREV TREATM
  • [10] Oxidative Stress in Preeclampsia and Placental Diseases
    Aouache, Rajaa
    Biquard, Louise
    Vaiman, Daniel
    Miralles, Francisco
    [J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2018, 19 (05)
12345678910