Multiple Sclerosis Is Rare in Epstein-Barr Virus-Seronegative Children with Central Nervous System Inflammatory Demyelination

被引：20

作者：

Nourbakhsh, Bardia ^{[1
]}

Cordano, Christian ^{[2
]}

Asteggiano, Carlo ^{[2
,3
]}

Ruprecht, Klemens ^{[4
,5
,6
,7
]}

Otto, Carolin ^{[4
,5
,6
,7
]}

Rutatangwa, Alice ^{[2
]}

Lui, Allysa ^{[2
]}

Hart, Janace ^{[2
]}

Flanagan, Eoin P. ^{[8
]}

James, Judith A. ^{[9
]}

Waubant, Emmanuelle ^{[2
]}

机构：

[1] Johns Hopkins Univ, Dept Neurol, Baltimore, MD 21218 USA

[2] Univ Calif San Francisco, Dept Neurol, San Francisco, CA USA

[3] Univ Pavia, Dept Brain & Behav Sci, Pavia, Italy

[4] Charite Univ Med Berlin, Dept Neurol, Berlin, Germany

[5] Free Univ Berlin, Berlin, Germany

[6] Humboldt Univ, Berlin, Germany

[7] Berlin Inst Hlth, Berlin, Germany

[8] Mayo Clin, Dept Neurol Lab Med & Pathol, Coll Med, Rochester, MN USA

[9] Oklahoma Med Res Fdn, Arthrit & Clin Immunol Dept, 825 NE 13th St, Oklahoma City, OK 73104 USA

来源：

ANNALS OF NEUROLOGY | 2021年 / 89卷 / 06期

基金：

美国国家卫生研究院;

关键词：

INFECTION; RISK;

D O I：

10.1002/ana.26062

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Although Epstein-Barr virus (EBV) is hypothesized to be a prerequisite for multiple sclerosis (MS), up to 15% of children with a diagnosis of MS were reported to be EBV-seronegative. When re-evaluating 25 EBV-seronegative children out of 189 pediatric patients with a diagnosis of clinically isolated syndrome/MS, we found anti-myelin oligodendrocyte glycoprotein (MOG) antibody in 11 of 25 (44%) EBV-seronegative but only 9 of 164 (5.5%, p < 0.001) EBV-seropositive patients. After critical review, MS remained a plausible diagnosis in only 4 of 14 EBV-seronegative/MOG antibody-negative patients. In children with an MS-like presentation, EBV seronegativity should alert clinicians to consider diagnoses other than MS, especially MOG-antibody disease. ANN NEUROL 2021

引用

页码：1234 / 1239

页数：6

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