Lithium and thyroid

被引：148
作者：
Lazarus, John H. [1 ]
机构：
[1] Cardiff Univ, Sch Med, Ctr Endocrine & Diabet Sci, Univ Wales Hosp, Cardiff CF14 4XN, S Glam, Wales
来源：
BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM | 2009年 / 23卷 / 06期
关键词：
autoimmunity; goitre; hyperthyroidism; hypothyroidism; physiology; TREATED PSYCHIATRIC-PATIENTS; FOLLOW-UP; RADIOIODINE THERAPY; MOLECULAR-MECHANISM; HORMONE METABOLISM; BIPOLAR DISORDER; ABNORMALITIES; TRIIODOTHYRONINE; HYPOTHYROIDISM; THYROTOXICOSIS;
D O I：
10.1016/j.beem.2009.06.002
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
One in 200 people receive lithium for treatment of bipolar disorder The common clinical side effects of the Chug are goitre in up to 40% and hypothyroidism in about 20% Lithium increases thyroid autoimmunity if present before therapy Treatment with levothyroxine is effective and lithium therapy should not be stopped Lithium may cause hyperthyroidism due to thyroiditis or rarely Graves' disease. As lithium inhibits thyroid hormone release from the thyroid gland it can be used as an adjunct therapy in the management of severe hyperthyroidism It also increases thyroidal radioiodine retention and may be effective in reducing administered activity in hyperthyroidism There is no clinical benefit of lithium therapy in thyroid cancer More research is required oil the Cellular proliferative effects Of lithium as well as its impact oil the immune system (C) 2009 Elsevier Ltd All rights reserved.
引用
收藏
页码：723 / 733
页数：11
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