Leptin inhibits food intake without affecting brain NOx levels in food-deprived mice

被引：1
|
作者：
Sugimoto, Y
Hirose, H
Yagura, T
Yamada, J
机构：
[1] Kobe Pharmaceut Univ, Dept Pharmacol, Higashinada Ku, Kobe, Hyogo 6588558, Japan
[2] Kwansei Gakuin Univ, Fac Sci & Technol, Dept Biosci, Sanda 6691337, Japan
来源：
BIOLOGICAL & PHARMACEUTICAL BULLETIN | 2003年 / 26卷 / 01期
关键词：
nitric oxide; food intake; NOx; hypothalamus; frontal cortex;
D O I：
10.1248/bpb.26.105
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Effects of leptin on food intake and nitric oxide (NO) metabolites (nitrite and nitrate, NOx) levels of brain were investigated in mice. Leptin dose-dependently decreased milk intake in food-deprived mice. Administration of leptin at a dose of 1 mg/kg, which induces an apparent hypophagia, did not affect NOx levels in the hypothalamus and frontal cortex. These results suggest that leptin reduces food intake in food-deprived mice without altering NO production in the hypothalamus, which plays an important role in regulation of feeding.
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收藏
页码：105 / 107
页数：3
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