Genetics of canine diabetes mellitus part 2: Current understanding and future directions

被引：4

作者：

Denyer, Alice L. ^{[1
]}

Catchpole, Brian ^{[1
]}

Davison, Lucy J. ^{[2
,3
]}

机构：

[1] Royal Vet Coll, Dept Pathol & Pathogen Biol, Hatfield, Herts, England

[2] Royal Vet Coll, Dept Clin Sci & Serv, Hatfield, Herts, England

[3] Univ Oxford, Wellcome Ctr Human Genet, Oxford, England

来源：

VETERINARY JOURNAL | 2021年 / 270卷

基金：

英国生物技术与生命科学研究理事会;

关键词：

Canine; Diabetes mellitus; Genetics; Genomics; Major histocompatibility complex; GENOME-WIDE ASSOCIATION; BETA-CELL FRAGILITY; CLASS-II ALLELES; INSULIN GENE; SULFONYLUREA RECEPTOR; SUSCEPTIBILITY GENES; MISSENSE MUTATIONS; TYPE-1; DOG; RISK;

D O I：

10.1016/j.tvjl.2021.105612

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

Part 1 of this 2-part review outlined the importance of disease classification in diabetes genetic studies, as well as the ways in which genetic variants may contribute to risk of a complex disease within an individual, or within a particular group of individuals. Part 2, presented here, describes in more detail our current understanding of the genetics of canine diabetes mellitus compared to our knowledge of the human disease. Ongoing work to improve our knowledge, using new technologies, is also introduced. ? 2021 Elsevier Ltd. All rights reserved.

引用

页数：9

共 83 条

[1] Latent Autoimmune Diabetes in Adults Differs Genetically From Classical Type 1 Diabetes Diagnosed After the Age of 35 Years [J].

Andersen, Mette K. ;

Lundgren, Virve ;

Turunen, Joni A. ;

Forsblom, Carol ;

Isomaa, Bo ;

Groop, Per-Henrik ;

Groop, Leif ;

Tuomi, Tiinamaija .

DIABETES CARE, 2010, 33 (09) :2062-2064

[2] Frequency and distribution of alleles of canine MHC-II DLA-DQB1, DLA-DQA1 and DLA-DRB1 in 25 representative American Kennel Club breeds [J].

Angles, JM ;

Kennedy, LJ ;

Pedersen, NC .

TISSUE ANTIGENS, 2005, 66 (03) :173-184

[3] Diabetes Mellitus and the β Cell: The Last Ten Years [J].

Ashcroft, Frances M. ;

Rorsman, Patrik .

CELL, 2012, 148 (06) :1160-1171

[4] DoGSD: the dog and wolf genome SNP database [J].

Bai, Bing ;

Zhao, Wen-Ming ;

Tang, Bi-Xia ;

Wang, Yan-Qing ;

Wang, Lu ;

Zhang, Zhang ;

Yang, He-Chuan ;

Liu, Yan-Hu ;

Zhu, Jun-Wei ;

Irwin, David M. ;

Wang, Guo-Dong ;

Zhang, Ya-Ping .

NUCLEIC ACIDS RESEARCH, 2015, 43 (D1) :D777-D783

[5] The Genetic Contribution to Type 1 Diabetes [J].

Bakay, Marina ;

Pandey, Rahul ;

Grant, Struan F. A. ;

Hakonarson, Hakon .

CURRENT DIABETES REPORTS, 2019, 19 (11)

[6] Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes [J].

Barrett, Jeffrey C. ;

Clayton, David G. ;

Concannon, Patrick ;

Akolkar, Beena ;

Cooper, Jason D. ;

Erlich, Henry A. ;

Julier, Cecile ;

Morahan, Grant ;

Nerup, Jorn ;

Nierras, Concepcion ;

Plagnol, Vincent ;

Pociot, Flemming ;

Schuilenburg, Helen ;

Smyth, Deborah J. ;

Stevens, Helen ;

Todd, John A. ;

Walker, Neil M. ;

Rich, Stephen S. .

NATURE GENETICS, 2009, 41 (06) :703-707

[7] SUSCEPTIBILITY TO HUMAN TYPE-1 DIABETES AT IDDM2 IS DETERMINED BY TANDEM REPEAT VARIATION AT THE INSULIN GENE MINISATELLITE LOCUS [J].

BENNETT, ST ;

LUCASSEN, AM ;

GOUGH, SCL ;

POWELL, EE ;

UNDLIEN, DE ;

PRITCHARD, LE ;

MERRIMAN, ME ;

KAWAGUCHI, Y ;

DRONSFIELD, MJ ;

POCIOT, F ;

NERUP, J ;

BOUZEKRI, N ;

CAMBONTHOMSEN, A ;

RONNINGEN, KS ;

BARNETT, AH ;

BAIN, SC ;

TODD, JA .

NATURE GENETICS, 1995, 9 (03) :284-292

[8] A functional variant of lymphoid tyrosine phosphatase is associated with type I diabetes [J].

Bottini, N ;

Musumeci, L ;

Alonso, A ;

Rahmouni, S ;

Nika, K ;

Rostamkhani, M ;

MacMurray, J ;

Meloni, GF ;

Lucarelli, P ;

Pellecchia, M ;

Eisenbarth, GS ;

Comings, D ;

Mustelin, T .

NATURE GENETICS, 2004, 36 (04) :337-338

[9] Future Roadmaps for Precision Medicine Applied to Diabetes: Rising to the Challenge of Heterogeneity [J].

Bowman, P. ;

Flanagan, S. E. ;

Hattersley, A. T. .

JOURNAL OF DIABETES RESEARCH, 2018, 2018

[10] A Genome-Wide Meta-Analysis of Six Type 1 Diabetes Cohorts Identifies Multiple Associated Loci [J].

Bradfield, Jonathan P. ;

Qu, Hui-Qi ;

Wang, Kai ;

Zhang, Haitao ;

Sleiman, Patrick M. ;

Kim, Cecilia E. ;

Mentch, Frank D. ;

Qiu, Haijun ;

Glessner, Joseph T. ;

Thomas, Kelly A. ;

Frackelton, Edward C. ;

Chiavacci, Rosetta M. ;

Imielinski, Marcin ;

Monos, Dimitri S. ;

Pandey, Rahul ;

Bakay, Marina ;

Grant, Struan F. A. ;

Polychronakos, Constantin ;

Hakonarson, Hakon .

PLOS GENETICS, 2011, 7 (09)

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