Antioxidant and antibacterial studies of arylazopyrazoles and arylhydrazonopyrazolones containing coumarin moiety

被引：107

作者：

Manojkumar, P. ^{[1
]}

Ravi, T. K. ^{[1
]}

Gopalakrishnan, S. ^{[1
]}

机构：

[1] Sri Ramakrishna Inst Paramed Sci, Dept Pharmaceut Chem, Coll Pharm, Coimbatore 641044, Tamil Nadu, India

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2009年 / 44卷 / 11期

关键词：

Antioxidant; Antibacterial; Pyrazole; LOW-DENSITY-LIPOPROTEIN; FREE-RADICAL SCAVENGER; BIOLOGICAL EVALUATION; DERIVATIVES;

D O I：

10.1016/j.ejmech.2009.07.004

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of novel 1-(4-methylcoumarinyl-7-oxyacetyl)-3,5-dimethyl-4(arylazo)pyrazoles and 1-(4-methylcoumarinyl-7-oxyacetyl)-3-methyl-4-(substituted phenyl) hydrazono-2-pyrazolin-5-ones were synthesised and evaluated for antibacterial and antioxidant activities. Compounds 3b, 3g, 5b, 5d and 5g showed good antibacterial activity and compound 5e was found to be the most active antioxidant in the series, and thus represent a new class of promising lead compounds. (C) 2009 Elsevier Masson SAS. All rights reserved.

引用

页码：4690 / 4694

页数：5

共 15 条

[1] Synthesis and biological evaluation of some thiazolyl and thiadiazolyl derivatives of 1H-pyrazole as anti-inflammatory antimicrobial agents [J].

Bekhit, Adnan A. ;

Ashour, Hayam M. A. ;

Ghany, Yasser S. Abdel ;

Bekhit, Alaa El-Din A. ;

Baraka, Azza .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2008, 43 (03) :456-463

[2]

Collins A.H., 1976, Microbiological Methods, Vsecond

[3]

Cruickshank R., 1975, Medicinal Microbiology, VII, P196

[4]

DHINGRA V, 1991, J INDIAN CHEM SOC, V68, P672

[5] Synthesis and antibacterial activity of quinolone-based compounds containing a coumarin moiety [J].

Emami, Saeed ;

Foroumadi, Alireza ;

Faramarzi, Mohammad A. ;

Samad, Nasrin .

ARCHIV DER PHARMAZIE, 2008, 341 (01) :42-48

[6]

Gupta U, 2004, INDIAN J HETEROCY CH, V13, P351

[7] Effect of the free radical scavenger, 3-methyl-1-phenyl-2-pyrazolin-5one (MCI-186), on hypoxia-ischemia-induced brain injury in neonatal rats [J].

Ikeda, T ;

Xia, YX ;

Kaneko, M ;

Sameshima, H ;

Ikenoue, T .

NEUROSCIENCE LETTERS, 2002, 329 (01) :33-36

[8] Novel 3,5-diaryl pyrazolines and pyrazole as low-density lipoprotein (LDL) oxidation inhibitor [J].

Jeong, TS ;

Kim, KS ;

Kim, JR ;

Cho, KH ;

Lee, S ;

Lee, WS .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2004, 14 (11) :2719-2723

[9]

Kalluraya B, 2007, INDIAN J HETEROCY CH, V17, P67

[10]

Khan MSY, 2003, INDIAN J CHEM B, V42, P900

← 1 2 →