Humoral and Cellular Response of Frontline Health Care Workers Infected by SARS-CoV-2 in Nice, France: A Prospective Single-Center Cohort Study

被引：6

作者：

Cremoni, Marion ^{[1
,2
]}

Ruetsch, Caroline ^{[3
]}

Zorzi, Kevin ^{[2
,4
]}

Fernandez, Celine ^{[2
,4
]}

Boyer-Suavet, Sonia ^{[2
,4
]}

Benzaken, Sylvia ^{[3
]}

Demonchy, Elisa ^{[5
]}

Dellamonica, Jean ^{[2
,6
]}

Ichai, Carole ^{[7
]}

Esnault, Vincent ^{[1
,2
,4
]}

Brglez, Vesna ^{[2
,4
]}

Seitz-Polski, Barbara ^{[1
,2
,3
,4
]}

机构：

[1] Univ Cote Azur, CHU Nice, Serv Nephrol Dialyse Transplantat, Nice, France

[2] Univ Cote Azur, Unite Rech Clin Cote Azur UR2CA, Nice, France

[3] Univ Cote Azur, CHU Nice, Lab Immunol, Nice, France

[4] Univ Cote Azur, CHU Nice, Ctr Reference Malad Rares Syndrome Nephrot Idiopa, Nice, France

[5] Univ Cote Azur, CHU Nice, Serv Infectiol, Nice, France

[6] Univ Cote Azur, CHU Nice, Serv Reanimat Med, Nice, France

[7] Univ Cote Azur, CHU Nice, Serv Reanimat Med Chirurg, Nice, France

来源：

FRONTIERS IN MEDICINE | 2021年 / 7卷

关键词：

health care workers; SARS-CoV-2; COVID-19; humoral response; cellular response; blood immune biomarkers; COVID-19;

D O I：

10.3389/fmed.2020.608804

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Frontline health care workers (HCWs) have been particularly exposed to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) since the start of the pandemic but the clinical features and immune responses of those infected with SARS-CoV-2 have not been well described. In a prospective single center cohort study, we enrolled 196 frontline HCWs exposed to the SARS-Cov-2 and 60 patients with moderate and severe forms of the coronavirus disease 2019 (COVID-19). Serological tests and cytokines assay were performed to analyze SARS-CoV-2-specific humoral and cellular immunity. Of the 196 HCWs tested, 15% had specific antibodies against SARS-CoV-2 and 45% of seropositive HCWs were strictly asymptomatic. However, in comparison to moderate and severe forms, HCWs with mild or asymptomatic forms of COVID-19 showed lower specific IgA and IgG peaks, consistent with their mild symptoms, and a robust immune cellular response, illustrated by a high production of type I and II interferons. Further studies are needed to evaluate whether this interferon functional immune assay, routinely applicable, can be useful in predicting the risk of severe forms of COVID-19.

引用

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