Adipocyte-myofibroblast transition as a possible pathophysiological step in androgenetic alopecia

被引：20
作者：
Kruglikov, Ilja L. [1 ]
Scherer, Philipp E. [2 ]
机构：
[1] Wellcomet GmbH, Dept Sci, Karlsruhe, Germany
[2] Univ Texas Southwestern Med Ctr Dallas, Dept Internal Med, Touchstone Diabet Ctr, Dallas, TX 75390 USA
来源：
EXPERIMENTAL DERMATOLOGY | 2017年 / 26卷 / 06期
关键词：
adipocyte-myofibroblast transition; androgenetic alopecia; perifollicular fibrosis; FIBROSIS; CELLS;
D O I：
10.1111/exd.13379
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
Appearance of local fibrotic structures around and beneath hair follicles during their involution is a known hallmark of androgenetic alopecia (AGA). We hypothesise that this fibrosis can be connected with recently uncovered adipocyte-myofibroblast transition (AMT) involving the dermal adipocytes. This reflects that AMT is at least partially androgen-dependent, and we propose that AMT may play a role in AGA.
引用
收藏
页码：522 / 523
页数：2
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