Efficacy and safety of sofosbuvir/simeprevir plus flat dose ribavirin in genotype 1 elderly cirrhotic patients: A real-life study

被引：11

作者：

Pellicelli, Adriano M. ^{[1
]}

Palitti, Valeria Pace ^{[2
]}

Vignally, Pascal ^{[3
]}

Ceccherini-Silberstein, Francesca ^{[4
]}

Siciliano, Massimo ^{[5
]}

Giannelli, Valerio ^{[1
]}

Moretti, Alessandra ^{[6
]}

Tarquini, Pierluigi ^{[7
]}

Scifo, Gaetano ^{[8
]}

Messina, Vincenzo ^{[9
]}

Ascione, Antonio ^{[10
]}

Izzi, Antonio ^{[11
]}

Marignani, Massimo ^{[12
]}

D'Ambrosio, Cecilia ^{[1
]}

Fondacaro, Lucia ^{[1
]}

Ettorre, Giuseppe M. ^{[13
]}

Ialongo, Pasquale ^{[14
]}

Sacco, Rodolfo ^{[15
]}

Perno, Carlo F. ^{[4
]}

Barbarini, Giorgio ^{[16
]}

机构：

[1] San Camillo Forlanini Hosp, Liver Dis Unit, Dept Liver Transplantat, Rome, Italy

[2] ASL Pescara, Hepatol Dept Med, Pescara, Italy

[3] Galliera Hosp, Emergency Dept, Genoa, Italy

[4] Univ Tor Vergata, Dept Expt Med & Surg, Rome, Italy

[5] Catholic Univ, Internal Med, Policlin Gemelli, Rome, Italy

[6] San Filippo Neri Hosp, Gastroenterol, Rome, Italy

[7] ASL Teramo, Infect Dis, Teramo, Italy

[8] Umberto Hosp, Infect Dis, Siracusa, Italy

[9] St Anna & San Sebastiano Hosp Caserta, Infect Dis, Rome, Italy

[10] Fatebenefratelli Hosp, Ctr Liver Dis, Naples, Italy

[11] Cotugno Hosp, Infect Dis, Naples, Italy

[12] Sapienza Univ Rome, S Andrea Hosp, Digest & Liver Dis Unit, Fac Med & Psychol, Rome, Italy

[13] S Camillo Forlanini Hosp, Div Gen Surg & Liver Transplantat, Rome, Italy

[14] Camillo Forlanini Hosp, Radiol, Rome, Italy

[15] Azienda Univ Pisana, Liver Unit, Pisa, Italy

[16] IRCCS San Matteo, Infect Dis, Pavia, Italy

来源：

LIVER INTERNATIONAL | 2017年 / 37卷 / 05期

关键词：

cirrhosis; elderly; genotype; 1; hepatitis C; simeprevir; sofosbuvir; HEPATITIS-C; PEGYLATED INTERFERON; ADVANCED FIBROSIS; SOFOSBUVIR; SIMEPREVIR; LEDIPASVIR; INFECTION; RECURRENCE;

D O I：

10.1111/liv.13288

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Background & Aims: The proportion of HCV-infected patients over age 65 years in Western countries is increasing. This growth and the advent of new antiviral therapy bring into the question the real-world efficacy and safety of the combination of sofosbuvir (SOF) and simeprevir (SMV) plus a flat dose of 800 mg/d ribavirin (RBV) in elderly patients with cirrhosis compared to younger patients. Methods: Retrospective observational multicentre real-life investigation study of SOF/SMV/RBV for a duration of 12 weeks in HCV genotype 1-infected patients with cirrhosis. Results: Of the 270 patients enrolled in this study, with compensated cirrhosis, 133 (49.2%) were >= 65 years of age. Sustained virological response at 12 weeks (SVR12) was achieved by 94.2% (129/137) of those aged <65 years and 97.7% (130/133) of those >= 65 years. Diabetes was the most common comorbidity in patients >= 65 years compared to younger patients (26.3% vs 12.4% P<.003). The most common adverse event (AE) in elderly patients was a grade 2 anaemia (35.3% vs 19.9% P<.004). Conclusions: Sofosbuvir/simeprevir plus a daily flat dose of RBV 800 mg for 12 weeks was highly effective and safe in genotype 1 elderly patients with compensated cirrhosis.

引用

页码：653 / 661

页数：9

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