Biomicrofluidics: Recent trends and future challenges

被引:24
作者
Das, Tamal [2 ]
Chakraborty, Suman [1 ]
机构
[1] Indian Inst Technol, Dept Mech Engn, Kharagpur 721302, W Bengal, India
[2] Indian Inst Technol, Dept Biotechnol, Kharagpur 721302, W Bengal, India
来源
SADHANA-ACADEMY PROCEEDINGS IN ENGINEERING SCIENCES | 2009年 / 34卷 / 04期
关键词
Microfluidics; biomicrofluidics; lab-on-a-chip; micro total analysis system (mu TAS); ON-A-CHIP; MICROFLUIDIC DEVICE; DNA HYBRIDIZATION; DRUG-DELIVERY; MICROCHIP ELECTROPHORESIS; ENZYME ASSAY; ELECTROKINETIC INSTABILITY; CAPILLARY-ELECTROPHORESIS; ANALYSIS SYSTEMS; SAMPLE STACKING;
D O I
10.1007/s12046-009-0035-8
中图分类号
T [工业技术];
学科分类号
08 ;
摘要
Biomicrofluidics is an active area of research at present, exploring the synergy of microfluidics with cellular and molecular biology, biotechnology, and biomedical engineering. The present article outlines the recent advancements in these areas, including the development of novel lab-on-a-chip based applications. Particular emphasis is given on the microfluidics-based handling of DNA, cells, and proteins, as well as fundamental microfluidic considerations for design of biomedical microdevices. Future directions of research on these topics are also discussed.
引用
收藏
页码:573 / 590
页数:18
相关论文
共 123 条
[1]   Gains in sensitivity with a device that mixes microarray hybridization solution in a 25-μm-thick chamber [J].
Adey, NB ;
Lei, M ;
Howard, MT ;
Jensen, JD ;
Mayo, DA ;
Butel, DL ;
Coffin, SC ;
Moyer, TC ;
Slade, DE ;
Spute, MK ;
Hancock, AM ;
Eisenhoffer, GT ;
Dalley, BK ;
McNeely, MR .
ANALYTICAL CHEMISTRY, 2002, 74 (24) :6413-6417
[2]   Generation of transverse fluid currents and forces by an electric field: Electro-osmosis on charge-modulated and undulated surfaces [J].
Ajdari, A .
PHYSICAL REVIEW E, 1996, 53 (05) :4996-5005
[3]   Transverse electrokinetic and microfluidic effects in micropatterned channels: Lubrication analysis for slab geometries [J].
Ajdari, A .
PHYSICAL REVIEW E, 2002, 65 (01) :1-016301
[4]   Microfabrication and microfluidics for tissue engineering: state of the art and future opportunities [J].
Andersson, H ;
van den Berg, A .
LAB ON A CHIP, 2004, 4 (02) :98-103
[5]   Micromachined flow-through filter-chamber for chemical reactions on beads [J].
Andersson, H ;
van der Wijngaart, W ;
Enoksson, P ;
Stemme, G .
SENSORS AND ACTUATORS B-CHEMICAL, 2000, 67 (1-2) :203-208
[6]   A rapid biosensor for viable B-anthracis spores [J].
Baeumner, AJ ;
Leonard, B ;
McElwee, J ;
Montagna, RA .
ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 2004, 380 (01) :15-23
[7]   RNA biosensor for the rapid detection of viable Escherichia coli in drinking water [J].
Baeumner, AJ ;
Cohen, RN ;
Miksic, V ;
Min, JH .
BIOSENSORS & BIOELECTRONICS, 2003, 18 (04) :405-413
[8]   Detection of viable oocysts of Cryptosporidium parvum following nucleic acid sequence based amplification [J].
Baeumner, AJ ;
Humiston, MC ;
Montagna, RA ;
Durst, RA .
ANALYTICAL CHEMISTRY, 2001, 73 (06) :1176-1180
[9]   Long-term monitoring of bacteria undergoing programmed population control in a microchemostat [J].
Balagaddé, FK ;
You, LC ;
Hansen, CL ;
Arnold, FH ;
Quake, SR .
SCIENCE, 2005, 309 (5731) :137-140
[10]   Theoretical prediction of fast 3D AC electro-osmotic pumps [J].
Bazant, Martin Z. ;
Ben, Yuxing .
LAB ON A CHIP, 2006, 6 (11) :1455-1461