HBV/HCV Coinfection in the Era of HCV-DAAs

被引：17

作者：

Abdelaal, Rashed ^{[1
,2
]}

Yanny, Beshoy ^{[1
,2
,3
]}

El Kabany, Mohamed ^{[1
,2
,3
]}

机构：

[1] Univ Calif Los Angeles, 200 Med Plaza,Suite 214, Los Angeles, CA 90095 USA

[2] Univ Calif Los Angeles, Dept Transplant Hepatol, Los Angeles, CA 90095 USA

[3] Univ Calif Los Angeles, Dept Med, Los Angeles, CA 90095 USA

来源：

CLINICS IN LIVER DISEASE | 2019年 / 23卷 / 03期

关键词：

Hepatitis B and C coinfection; Sustained viral response; Hepatitis B reactivation; HEPATITIS-B-VIRUS; ACTING ANTIVIRAL TREATMENT; C VIRUS; REACTIVATION; INFECTION; RISK; SOFOSBUVIR; THERAPY; DACLATASVIR; ASUNAPREVIR;

D O I：

10.1016/j.cld.2019.04.003

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Epidemiologic studies suggest that 10% to 15% of patients infected with hepatitis C virus (HCV) are coinfected with hepatitis B virus (HBV) in the United States as a result of the shared modality of transmission, but the true prevalence is not known. The progression of liver disease to cirrhosis and hepatocellular carcinoma is generally faster in patients who are coinfected, and HCV is usually more predominant. Immunosuppression of the host or eradication of hepatitis C can change this paradigm, causing hepatitis B reactivation. This review describes HCV-HBV viral interactions, risks for reactivation, screening, and society guidelines for surveillance and treatment.

引用

页码：463 / +

页数：11

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