Synthesis and SAR of 2-(4-fluorophenyl)-3-pyrimidin-4-ylimidazo[1,2-a]pyridine derivatives as anticoccidial agents

被引：19

作者：

Feng, Dennis

Fisher, Michael

Liang, Gui-Bai

Qian, Xiaoxia

Brown, Chris

Gurnett, Anne

Leavitt, Penny Sue

Liberator, Paul A.

Mathew, John

Misura, Andrew

Samaras, Samantha

Tamas, Tamas

Schmatz, Dennis M.

Wyvratt, Matthew

Biftu, Tesfaye

机构：

[1] Merck & Co Inc, Dept Med Chem, Merck Res Labs, Rahway, NJ 07065 USA

[2] Merck & Co Inc, Human & Anim Infect Dis Res, Rahway, NJ 07065 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2006年 / 16卷 / 23期

关键词：

kinase; coccidiosis; parasite; imidazopyrimidine; PKG inhibitor;

D O I：

10.1016/j.bmcl.2006.08.127

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Compounds 10a-10d and 10i are very potent inhibitors of Eimeria tenella cGMP-dependent protein kinase (0.081-0.32 nM) and are very efficacious antiparasitic agents in vivo when administered to chickens at 12.5-25 ppm levels in the feed. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：5978 / 5981

页数：4

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