Convenient Large-Scale Synthesis of D-Glucaro-1,4:6,3-dilactone

被引：12

作者：

Gehret, Troy C. ^{[1
]}

Frobese, A. Stephen ^{[1
]}

Zerbe, James S. ^{[1
]}

Chenault, H. Keith ^{[1
]}

机构：

[1] EI DuPont Nemours & Co, Cent Res & Dev, Expt Stn, Wilmington, DE 19880 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2009年 / 74卷 / 21期

关键词：

HIV-1 PROTEASE INHIBITORS; RING-OPENING POLYADDITION; D-GLUCARIC ACID; ACTIVE POLYCONDENSATION; HYDROXYLATED NYLONS; MACROMOLECULAR-SYNTHESIS; HYDROPHILIC POLYAMIDE; GLUCOSACCHARIC ACID; SACCHARIC LACTONES; BETA-GLUCURONIDASE;

D O I：

10.1021/jo9015985

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Calcium D-glucarate was converted into D-glucaro-1,4:6,3-dilactone on 32-g, 1-kg, and 22-kg scale, using azeotropic distillation with methyl isobutyl ketone to drive the dehydration. The crystalline product was >= 99.5% pure by GC and NMR, and overall yield was its high as 72%.

引用

页码：8373 / 8376

页数：4

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