Lipopolysaccharide binding protein and sCD14 as risk markers of stroke-associated pneumonia

被引：4
作者：
Gradek-Kwinta, Elzbieta [1 ]
Czyzycki, Mateusz [1 ]
Lopatkiewicz, Anna Maria [1 ]
Klimiec-Moskal, Elzbieta [1 ]
Slowik, Agnieszka [1 ]
Dziedzic, Tomasz [1 ]
机构：
[1] Jagiellonian Univ Med Coll, Dept Neurol, Ul Botaniczna 3, PL-31503 Krakow, Poland
来源：
JOURNAL OF NEUROIMMUNOLOGY | 2021年 / 354卷
关键词：
Pneumonia; Stroke; Biomarker; LBP; sCD14; Inflammation; PLASMA ENDOTOXIN; CD14; INFECTIONS;
D O I：
10.1016/j.jneuroim.2021.577532
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
To determine the utility of lipopolysaccharide binding protein (LBP) and soluble CD14 (sCD14) as risk markers of stroke-associated pneumonia (SAP). We included 331 stroke patients. The plasma levels of LBP (median: 19.4 vs 15.3 mu g/mL, P < 0.01) and sCD14 (median: 1.5 vs 1.4 mu g/mL, P = 0.04) were elevated in SAP. In multivariate analysis, a higher level of LBP (OR: 1.09, 95%CI: 1.05-1.13), but not sCD14 (OR: 2.16, 0.94-4.97), was associated with SAP. The addition of LBP or sCD14 to the clinical model did not improve its discriminatory ability. Our results suggest the modest value of studied biomarkers for SAP prediction.
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页数：4
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