Multi-oxygenase complexes of the gilvocarcin and jadomycin biosyntheses

被引：58

作者：

Kharel, Madan K. ^{[1
]}

Zhu, Lili ^{[1
]}

Liu, Tao ^{[1
]}

Rohr, Juergen ^{[1
]}

机构：

[1] Univ Kentucky, Coll Pharm, Dept Pharmaceut Sci, Lexington, KY 40536 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2007年 / 129卷 / 13期

关键词：

D O I：

10.1021/ja0680515

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A series of gene inactivation and gene recombination experiments involving oxygenase encoding genes of the gilvocarcin and jadomycin biosynthetic pathways showed that the enigmatic oxidative rearrangement cascades in these pathways is catalyzed by multi-oxygenase complexes and follows almost identical paths up through the C-C bond cleavage reaction. The two pathways branch beyond this key reaction and end up eventually in the unique tetracyclic benzo[d]naphtho[1,2-b]pyran-6-one and pentacyclic benz[b]oxazolophenanthridine backbones, respectively, typical for these groups of anticancer antibiotics.

引用

页码：3780 / +

页数：3

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